Ngo Nhi T N, Nguyen Ha Thi, Nguyen Phuong Thi Lan, Vo Truc Thuy Thanh, Phung Toi Lam, Pham Anh Gia, Vo Thanh Van, Dang Mai Thi Ngoc, Nguyen Le Bao Tien, Duong Khanh N C
School of Medicine, Vietnam National University, Ho Chi Minh, Vietnam.
Ministry of Health, Health Strategy and Policy Institute, Ha Noi, Vietnam.
Front Glob Womens Health. 2023 Jun 14;4:1180383. doi: 10.3389/fgwh.2023.1180383. eCollection 2023.
Breast cancer remains one of the major cancers worldwide. In Asia, breast cancer is leading both incidence and mortality rates. Health-related quality of life (HRQoL) studies play an important role in clinical treatment. This systematic review aimed to summarize the evidence of HRQoL and associated factors among patients with breast cancer in low-and-middle-income countries (LMICs) in Asia.
Performed according to PRISMA guidelines for systematic review, the studies were searched from three databases (PubMed, Cochrane, Scopus) up to November 2020. The studies which met the predefined eligibility criteria were selected, extracted, and assessed the quality according to the Newcastle-Ottawa Scale (NOS) tool.
A total of 2,620 studies were searched on the three databases, of which 28 met the selection criteria, then, were included in the systematic review. The Global Health Status (GHS) score of breast cancer patients based on the EORTC QLQ-C30 questionnaire ranged from 56.32 ± 25.42 to 72.48 ± 15.68. The overall HRQoL scores using the FACT-G and FACT-B instruments ranged from 60.78 ± 13.27 to 82.23 ± 12.55 and from 70.29 ± 13.33 to 108.48 ± 19.82, respectively. Factors affecting HRQoL of patients with breast cancer included age, education level, income, marital status, lifestyle, tumor stage, method, and treatment duration. Patient's income showed a consistent effect on HRQoL while the remaining factors reported inconsistent findings across the studies. In conclusion, the HRQoL of breast cancer patients in LMICs in Asia was low and affected by several sociodemographic factors which should be studied more in future research.
乳腺癌仍然是全球主要癌症之一。在亚洲，乳腺癌的发病率和死亡率均位居前列。健康相关生活质量（HRQoL）研究在临床治疗中发挥着重要作用。本系统评价旨在总结亚洲低收入和中等收入国家（LMICs）乳腺癌患者HRQoL及相关因素的证据。
按照PRISMA系统评价指南进行，截至2020年11月从三个数据库（PubMed、Cochrane、Scopus）检索研究。选择符合预定义纳入标准的研究，提取并根据纽卡斯尔-渥太华量表（NOS）工具评估质量。
在三个数据库中共检索到2620项研究，其中28项符合纳入标准，随后被纳入系统评价。基于欧洲癌症研究与治疗组织QLQ-C30问卷的乳腺癌患者全球健康状况（GHS）评分范围为56.32±25.42至72.48±15.68。使用FACT-G和FACT-B工具的总体HRQoL评分分别为60.78±13.27至82.23±12.55以及70.29±13.33至108.48±19.82。影响乳腺癌患者HRQoL的因素包括年龄、教育水平、收入、婚姻状况、生活方式、肿瘤分期、治疗方法和治疗持续时间。患者收入对HRQoL有一致影响，而其余因素在各项研究中报告的结果不一致。总之亚洲LMICs乳腺癌患者的HRQoL较低，且受多种社会人口学因素影响，未来研究应更多地对此进行探讨。
