50 ppm二氧化氮气体暴露对大鼠生理功能的影响。

Effects of 50 ppm NO2 gas exposure on physiological functions of rats.

作者信息

Shimizu T, Sotokawa H, Hatano M, Izumiyama M, Otomo H, Kogure K

出版信息

Toxicol Lett. 1986 Jul-Aug;32(1-2):29-36. doi: 10.1016/0378-4274(86)90045-7.

Abstract

When rats were exposed to 50 ppm NO2 gas for 36 h, remarkable changes in some biochemical levels compared with those of control rats were observed. Namely, levels of total cholesterol, ester cholesterol, total lipids, triglycerides, nitrogen of urea, uric acid, glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and cytochrome P-450 of the exposed rats were decidedly different from those of the control rats. Thus, it was suggested that functions of liver are acutely injured upon exposure to 50 ppm NO2 gas, although extensive pulmonary injury resulting from such an exposure may also be responsible for some of the abnormal serum values.

摘要

当大鼠暴露于50 ppm二氧化氮气体中36小时后，与对照大鼠相比，观察到一些生化水平发生了显著变化。具体而言，暴露组大鼠的总胆固醇、酯胆固醇、总脂质、甘油三酯、尿素氮、尿酸、谷草转氨酶（GOT）、谷丙转氨酶（GPT）、乳酸脱氢酶（LDH）、碱性磷酸酶（ALP）和细胞色素P - 450水平与对照大鼠明显不同。因此，有人认为暴露于50 ppm二氧化氮气体时肝脏功能会受到急性损伤，尽管这种暴露导致的广泛肺损伤也可能是一些血清异常值的原因之一。