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实验动物中与二硫化碳肝毒性相关的血清酶变化。

Serum enzyme changes associated with carbon disulfide hepatotoxicity in experimental animals.

作者信息

El-Dessoukey E A, Awadallah R, Mikhail T H

出版信息

Z Ernahrungswiss. 1977 Dec;16(4):262-7. doi: 10.1007/BF02023706.

DOI:10.1007/BF02023706
PMID:605628
Abstract

Investigations were performed to evaluate the activities of serum glutamic oxalacetic and glutamic pyruvic transaminases, alkaline phosphatase and lactate-dehydrogenase enzymes in rats intoxicated by different doses of carbon disulfide. Serum GOT and GPT activities were elevated which may be due to CS2 effect on cell membrane permeability. Serum-alkaline-phosphatase activity showed also increment, which was again attributed to the liver affection. A significant rise in serum-lactate-dehydrogenase activity which was referred to be as a result of muscle-lactate dehydrogenase release into the blood circulation.

摘要

进行了多项研究，以评估不同剂量二硫化碳中毒大鼠血清中的谷氨酸草酰乙酸转氨酶、谷氨酸丙酮酸转氨酶、碱性磷酸酶和乳酸脱氢酶的活性。血清谷草转氨酶和谷丙转氨酶活性升高，这可能是由于二硫化碳对细胞膜通透性的影响。血清碱性磷酸酶活性也有所增加，这同样归因于肝脏受到影响。血清乳酸脱氢酶活性显著升高，这被认为是肌肉中的乳酸脱氢酶释放到血液循环中的结果。

相似文献

1
Serum enzyme changes associated with carbon disulfide hepatotoxicity in experimental animals.实验动物中与二硫化碳肝毒性相关的血清酶变化。
Z Ernahrungswiss. 1977 Dec;16(4):262-7. doi: 10.1007/BF02023706.
2
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本文引用的文献

1
A CONVENIENT METHOD FOR DETERMINING SERUM AND BILE PHOSPHATASE ACTIVITY.一种测定血清和胆汁磷酸酶活性的简便方法。
Can Med Assoc J. 1934 Oct;31(4):376-81.
2
The relationship of dietary factors to rat serum alkaline phosphatase. II. The effect of total food consumption, methionine, choline, and vitamin B12 in normal and alloxan diabetic adult rats.饮食因素与大鼠血清碱性磷酸酶的关系。II. 正常和四氧嘧啶糖尿病成年大鼠的食物总摄入量、蛋氨酸、胆碱和维生素B12的影响。
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[Histopathological note on chronic experimental carbon disulfide poisoning].
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Folia Med (Napoli). 1954 Jun;37(6):466-73.
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The clinical significance of transaminase activities of serum.血清转氨酶活性的临床意义。
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A study of carbon tetrachloride. II. The effect of carbon tetrachloride inhalation on serum and tissue enzymes.
Arch Environ Health. 1960 Aug;1:96-100. doi: 10.1080/00039896.1960.10662672.
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Biochemical mechanisms in chronic carbon disulfide poisoning.慢性二硫化碳中毒的生化机制
Am Ind Hyg Assoc J. 1959 Aug;20(4):303-23. doi: 10.1080/00028895909343722.
7
[Activity determination of enzymes of energy-producing metabolism in human serum and liver punctate in liver diseases; enzyme activity determination in human liver. III].[人类血清和肝脏疾病中肝脏穿刺组织能量产生代谢相关酶的活性测定；人类肝脏中酶活性的测定。III]
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8
Skin absorption of carbon disulfide vapor in rabbits. I. Associated changes in blood protein and zinc.家兔对二硫化碳蒸气的皮肤吸收。I. 血液蛋白质和锌的相关变化
AMA Arch Ind Health. 1958 Feb;17(2):164-9.
9
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.一种测定血清谷草转氨酶和谷丙转氨酶的比色法。
Am J Clin Pathol. 1957 Jul;28(1):56-63. doi: 10.1093/ajcp/28.1.56.
10
[Determination of sulfhydryl groups in blood serum following exposure to carbon disulfide].[二硫化碳暴露后血清中巯基的测定]
Bull Soc Chim Biol (Paris). 1955;37(12):1373-8.