2nd Orthopaedic Department, G. Papageorgiou General Hospital, Thessaloniki, Greece.
Orthopaedic Surgeon, Thessaloniki, Greece.
Injury. 2023 Aug;54(8):110888. doi: 10.1016/j.injury.2023.110888. Epub 2023 Jun 19.
This narrative review aims to investigate the effects of drugs on implant osseointegration, analyzing their potential positive or negative impact on the direct structural and functional connection between bone and load-carrying implants.
The review seeks to provide a comprehensive understanding of osseointegration, which refers to the successful integration of an implant with living bone, resulting in no progressive relative movement between them. Exploring the effects of drugs on implant osseointegration is crucial for optimizing outcomes and enhancing patient care in orthopedic implant procedures.
Relevant studies on the effects of drugs on implant osseointegration were identified through a literature search. Electronic databases, including PubMed, Embase, and Google Scholar, were utilized, employing appropriate keywords and MeSH terms related to osseointegration, implants, and drug interventions. The search was limited to English studies.
This overview presents a detailed analysis of the effects of drugs on implant osseointegration. It explores drugs such as bisphosphonates, teriparatide, statins, angiotensin-converting enzyme inhibitors, beta-blockers, nitrites, and thiazide diuretics as promoters of osseointegration. Conversely, loop diuretics, non-steroidal anti-inflammatory drugs, corticosteroids, cyclosporine A, cisplatin, methotrexate, antibiotics, proton pump inhibitors (PPIs), antiepileptics, selective serotonin reuptake inhibitors (SSRIs), and anticoagulants are discussed as inhibitors of the process. The role of vitamin D3 remains uncertain. The complex relationship between drugs and the biology of implant osseointegration is emphasized, underscoring the need for further in vitro and in vivo studies to validate their effects CONCLUSION: This narrative review contributes to the literature by providing an overview of the effects of drugs on implant osseointegration. It highlights the complexity of the subject and emphasizes the necessity for more extensive and sophisticated studies in the future. Based on the synthesis of the reviewed literature, certain drugs, such as bisphosphonates and teriparatide, show potential for promoting implant osseointegration, while others, including loop diuretics and certain antibiotics, may impede the process. However, additional research is required to solidify these conclusions and effectively inform clinical practice.
本叙述性综述旨在探讨药物对种植体骨整合的影响，分析它们对骨与承重种植体之间直接结构和功能连接的潜在积极或消极影响。
综述旨在提供对骨整合的全面理解，即种植体与活骨成功整合，导致它们之间没有进行性相对运动。探索药物对种植体骨整合的影响对于优化骨科植入手术的结果和增强患者护理至关重要。
通过文献检索确定了关于药物对种植体骨整合影响的相关研究。使用电子数据库，包括 PubMed、Embase 和 Google Scholar，并使用与骨整合、植入物和药物干预相关的适当关键词和 MeSH 术语进行搜索。搜索仅限于英文研究。
本综述详细分析了药物对种植体骨整合的影响。它探讨了促进骨整合的药物，如双膦酸盐、特立帕肽、他汀类药物、血管紧张素转换酶抑制剂、β受体阻滞剂、亚硝酸盐和噻嗪类利尿剂。相反，袢利尿剂、非甾体抗炎药、皮质类固醇、环孢素 A、顺铂、甲氨蝶呤、抗生素、质子泵抑制剂（PPIs）、抗癫痫药、选择性 5-羟色胺再摄取抑制剂（SSRIs）和抗凝剂被讨论为该过程的抑制剂。维生素 D3 的作用仍不确定。强调了药物与种植体骨整合生物学之间复杂的关系，需要进一步进行体外和体内研究来验证它们的效果。
本叙述性综述通过提供药物对种植体骨整合影响的概述，为文献做出了贡献。它突出了该主题的复杂性，并强调了未来进行更广泛和复杂研究的必要性。基于综述文献的综合分析，某些药物，如双膦酸盐和特立帕肽，显示出促进种植体骨整合的潜力，而其他药物，如袢利尿剂和某些抗生素，可能会阻碍该过程。然而，需要进一步的研究来巩固这些结论，并有效地为临床实践提供信息。
