Mohammadi Aida, Dehkordi Nazanin Roqani, Mahmoudi Sadaf, Rafeie Niyousha, Sabri Hamoun, Valizadeh Maryam, Poorsoleiman Taniya, Jafari Aryan, Mokhtari Alireza, Khanjarani Arshia, Salimi Yasaman, Mokhtari Melika, Deravi Niloofar
Dental Materials Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Periodontology, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Curr Rev Clin Exp Pharmacol. 2023;19(1):42-60. doi: 10.2174/2772432817666220607114559.
Dental implants have been one of the most popular treatments for rehabilitating individuals with single missing teeth or fully edentulous jaws since their introduction. As more implant patients are well-aged and take several medications due to various systemic conditions, clinicians should take into consideration the possible drug implications on bone remodeling and osseointegration.
The present study aims to examine and review some desirable and unwelcomed implications of medicine on osseointegration.
A broad search for proper relevant studies was conducted in four databases, including Web of Science, Pubmed, Scopus, and Google Scholar.
Some commonly prescribed medicines, such as nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, proton pump inhibitors (PPIs), selective serotonin reuptake inhibitors (SSRIs), anticoagulants, metformin, and chemotherapeutic agents, may jeopardize osseointegration. On the contrary, some therapeutic agents, such as anabolic, anti-catabolic, or dual anabolic agents may enhance osseointegration and increase the treatment's success rate.
Systemic medications that enhance osseointegration include mineralization promoters and bone resorption inhibitors. On the other hand, medications often given to the elderly with systemic problems might interfere with osseointegration, leading to implant failure. However, to validate the research, more human studies with a higher level of evidence are required.
自牙科种植体问世以来，它一直是修复单颗牙齿缺失或全口无牙颌患者最常用的治疗方法之一。由于越来越多的种植患者年龄较大且因各种全身疾病服用多种药物，临床医生应考虑药物对骨重塑和骨结合可能产生的影响。
本研究旨在探讨和综述药物对骨结合的一些有利和不利影响。
在四个数据库中广泛检索相关研究，包括科学网、PubMed、Scopus和谷歌学术。
一些常用药物，如非甾体抗炎药（NSAIDs）、糖皮质激素、质子泵抑制剂（PPIs）、选择性5-羟色胺再摄取抑制剂（SSRIs）、抗凝剂、二甲双胍和化疗药物，可能会损害骨结合。相反，一些治疗药物，如合成代谢、抗分解代谢或双重合成代谢药物，可能会增强骨结合并提高治疗成功率。
增强骨结合的全身用药包括矿化促进剂和骨吸收抑制剂。另一方面，给有全身问题的老年人常用的药物可能会干扰骨结合，导致种植失败。然而，为了验证该研究，需要更多证据水平更高的人体研究。
