Graduate School of Design and Architecture, Nagoya City University, Nagoya 464-0083, Japan.
Ritsumeikan University, Osaka 567-8570, Japan.
Drug Discov Today. 2023 Aug;28(8):103677. doi: 10.1016/j.drudis.2023.103677. Epub 2023 Jun 28.
Alzheimer's disease (AD) has no effective treatment, although antibody drugs targeting beta-amyloid, mainly aducanumab, have produced useful clinical results. Biomarkers can be used to determine drug regimens effectively and to monitor the effects of drugs. A concept in which biomarkers reflect disease states is emerging. Although several AD biomarker studies have been reported, measurement methods and target molecules are still being validated, and various biomarkers are being explored. This study analyzed trends in research on AD biomarkers using bibliometric methods, revealing an exponential increase in research reports in this field, with the US most active in research. Analysis of the 'Burst' biomarkers using CiteSpace revealed that networks centered on authors, rather than networks among countries, drive new research trends in this area.
阿尔茨海默病(AD)目前尚无有效治疗方法,尽管针对β-淀粉样蛋白的抗体药物(主要是 aducanumab)已取得了有益的临床效果。生物标志物可用于有效确定药物方案,并监测药物的效果。生物标志物反映疾病状态的概念正在出现。尽管已经报道了几项 AD 生物标志物研究,但测量方法和靶分子仍在验证中,并且正在探索各种生物标志物。本研究使用文献计量学方法分析了 AD 生物标志物研究的趋势,显示该领域的研究报告呈指数增长,美国在研究方面最为活跃。使用 CiteSpace 对“突发”生物标志物进行分析表明,推动该领域新研究趋势的是作者网络,而不是国家间网络。
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