文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

全球阿尔茨海默病研究中的生物标志物趋势:文献计量分析。

Global biomarker trends in Alzheimer's research: A bibliometric analysis.

机构信息

Graduate School of Design and Architecture, Nagoya City University, Nagoya 464-0083, Japan.

Ritsumeikan University, Osaka 567-8570, Japan.

出版信息

Drug Discov Today. 2023 Aug;28(8):103677. doi: 10.1016/j.drudis.2023.103677. Epub 2023 Jun 28.


DOI:10.1016/j.drudis.2023.103677
PMID:37390962
Abstract

Alzheimer's disease (AD) has no effective treatment, although antibody drugs targeting beta-amyloid, mainly aducanumab, have produced useful clinical results. Biomarkers can be used to determine drug regimens effectively and to monitor the effects of drugs. A concept in which biomarkers reflect disease states is emerging. Although several AD biomarker studies have been reported, measurement methods and target molecules are still being validated, and various biomarkers are being explored. This study analyzed trends in research on AD biomarkers using bibliometric methods, revealing an exponential increase in research reports in this field, with the US most active in research. Analysis of the 'Burst' biomarkers using CiteSpace revealed that networks centered on authors, rather than networks among countries, drive new research trends in this area.

摘要

阿尔茨海默病(AD)目前尚无有效治疗方法,尽管针对β-淀粉样蛋白的抗体药物(主要是 aducanumab)已取得了有益的临床效果。生物标志物可用于有效确定药物方案,并监测药物的效果。生物标志物反映疾病状态的概念正在出现。尽管已经报道了几项 AD 生物标志物研究,但测量方法和靶分子仍在验证中,并且正在探索各种生物标志物。本研究使用文献计量学方法分析了 AD 生物标志物研究的趋势,显示该领域的研究报告呈指数增长,美国在研究方面最为活跃。使用 CiteSpace 对“突发”生物标志物进行分析表明,推动该领域新研究趋势的是作者网络,而不是国家间网络。

相似文献

[1]
Global biomarker trends in Alzheimer's research: A bibliometric analysis.

Drug Discov Today. 2023-8

[2]
Bibliometric review on biomarkers for Alzheimer's disease between 2000 and 2023.

Medicine (Baltimore). 2023-9-8

[3]
Aducanumab, gantenerumab, BAN2401, and ALZ-801-the first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval.

Alzheimers Res Ther. 2020-8-12

[4]
Alzheimer's disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?

Biochem Pharmacol. 2020-4-2

[5]
Potential eligibility for Aducanumab therapy in an Irish specialist cognitive service-Utilising cerebrospinal fluid biomarkers and appropriate use criteria.

Int J Geriatr Psychiatry. 2022-8

[6]
A Primer on the Evolution of Aducanumab: The First Antibody Approved for Treatment of Alzheimer's Disease.

J Alzheimers Dis. 2021

[7]
Aducanumab: The first targeted Alzheimer's therapy.

Drug Discov Ther. 2021

[8]
The Alzheimer's disease drug development landscape.

Alzheimers Res Ther. 2021-11-11

[9]
Application of the NIA-AA Research Framework: Towards a Biological Definition of Alzheimer's Disease Using Cerebrospinal Fluid Biomarkers in the AIBL Study.

J Prev Alzheimers Dis. 2019

[10]
Plasma neurofilament L to amyloid β42 ratio in differentiating Alzheimer's type from non-Alzheimer's dementia: A cross-sectional pilot study from India.

Asian J Psychiatr. 2021-12

引用本文的文献

[1]
Mass spectrometry-based methods for biofluid biomarkers for progressive diseases: amyloid peptides and dystrophins.

Bioanalysis. 2025-5

[2]
Structural and temporal dynamics analysis on immune response in low-dose radiation: History, research hotspots and emerging trends.

World J Radiol. 2025-4-28

[3]
Global research trends on the links between gut microbiota and radiotherapy: a bibliometric analysis (2004-2023).

Front Cell Infect Microbiol. 2024

[4]
Mapping Knowledge Landscapes and Emerging Trends in AI for Dementia Biomarkers: Bibliometric and Visualization Analysis.

J Med Internet Res. 2024-8-8

[5]
Bibliometric analysis of neuroinflammation and Alzheimer's disease.

Front Aging Neurosci. 2024-7-15

[6]
Top 100 most-cited articles on tau protein: a bibliometric analysis and evidence mapping.

Front Neurosci. 2024-1-31

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索