Sun Wenxian, Gong Jin, Li Shaoqi, Wang Pin, Han Xiaodong, Xu Chang, Luan Heya, Li Ruina, Wen Boye, Wei Cuibai
Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
Front Aging Neurosci. 2024 Jul 15;16:1423139. doi: 10.3389/fnagi.2024.1423139. eCollection 2024.
BACKGROUND: Alzheimer's disease (AD) is the predominant cause of dementia on a global scale, significantly impacting the health of the elderly population. The pathogenesis of AD is closely linked to neuroinflammation. The present study employs a bibliometric analysis to examine research pertaining to neuroinflammation and AD within the last decade, with the objective of providing a comprehensive overview of the current research profile, hotspots and trends. METHODS: This research conducted a comprehensive review of publications within the Science Citation Index Expanded of the Web of Science Core Collection Database spanning the years 2014 to 2024. Bibliometric analyses were performed using VOSviewer (version 1.6.19) and CiteSpace (version 6.3.R1) software to visualize data on countries, institutions, authors, journals, keywords, and references. RESULTS: A total of 3,833 publications on neuroinflammation and AD were included from January 2014 to January 2024. Publications were mainly from the United States and China. Zetterberg, Henrik emerged as the author with the highest publication output, while Edison, Paul was identified as the most cited author. The most productive journal was Journal of Alzheimers Disease, and the most co-cited was Journal of Neuroinflammation. Research hotspot focused on microglia, mouse models, oxidative stress, and amyloid-beta through keyword analysis. Additionally, keywords such as blood-brain barrier and tau protein exhibited prolonged citation bursts from 2022 to 2024. CONCLUSION: This study provides a comprehensive review of the last 10 years of research on neuroinflammation and AD, including the number and impact of research findings, research hotspots, and future trends. The quantity of publications in this field is increasing, mainly in the United States and China, and there is a need to further strengthen close cooperation with different countries and institutions worldwide. Presently, research hotspots are primarily concentrated on microglia, with a focus on inhibiting their pro-inflammatory responses and promoting their anti-inflammatory functions as a potential direction for future investigations.
背景：阿尔茨海默病（AD）是全球范围内痴呆症的主要病因，对老年人群的健康产生重大影响。AD的发病机制与神经炎症密切相关。本研究采用文献计量分析方法，对过去十年中与神经炎症和AD相关的研究进行考察，旨在全面概述当前的研究概况、热点及趋势。 方法：本研究对2014年至2024年期间Web of Science核心合集数据库中科学引文索引扩展版收录的出版物进行了全面回顾。使用VOSviewer（1.6.19版本）和CiteSpace（6.3.R1版本）软件进行文献计量分析，以可视化关于国家、机构、作者、期刊、关键词和参考文献的数据。 结果：2014年1月至2024年1月期间，共纳入3833篇关于神经炎症和AD的出版物。出版物主要来自美国和中国。亨里克·泽特伯格是发文量最高的作者，而保罗·爱迪生是被引用次数最多的作者。发文量最多的期刊是《阿尔茨海默病杂志》，被共引次数最多的是《神经炎症杂志》。通过关键词分析，研究热点集中在小胶质细胞、小鼠模型、氧化应激和β淀粉样蛋白。此外，血脑屏障和tau蛋白等关键词在2022年至2024年期间呈现出较长时间的引用爆发。 结论：本研究对过去十年神经炎症和AD的研究进行了全面综述，包括研究成果的数量和影响、研究热点及未来趋势。该领域的出版物数量在增加，主要集中在美国和中国，有必要进一步加强与全球不同国家和机构的紧密合作。目前，研究热点主要集中在小胶质细胞，抑制其促炎反应并促进其抗炎功能作为未来研究的潜在方向。
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