Smith G R, Turner A, Cinderey R
Vet Rec. 1986 Jun 21;118(25):691-3. doi: 10.1136/vr.118.25.691.
Wallabies (Macropus rufogriseus) were not appreciably more susceptible than rabbits or mice to Fusobacterium necrophorum, a fact established by the subcutaneous injection of a series of graded doses into animals of each species. The strikingly frequent occurrence of necrobacillosis in captive macropods is therefore not due to a uniquely high susceptibility. A vaccine containing inactivated F necrophorum culture emulsified with Freund's complete adjuvant failed to increase the resistance of wallabies to subcutaneous challenge with a moderate dose of the homologous strain. The control of necrobacillosis in captive wallabies must therefore depend on managemental measures aimed at minimising faecal contamination of the environment and damage to the buccal mucous membrane and skin.
通过给袋鼠（褐大袋鼠）、兔子和小鼠皮下注射一系列梯度剂量的坏死梭杆菌，发现袋鼠对该菌的易感性并不比兔子或小鼠更高。因此，圈养有袋动物中坏死杆菌病的频繁发生并非由于其独特的高易感性。一种含有用弗氏完全佐剂乳化的灭活坏死梭杆菌培养物的疫苗，未能提高袋鼠对中等剂量同源菌株皮下攻击的抵抗力。因此，圈养袋鼠坏死杆菌病的控制必须依赖于旨在尽量减少环境粪便污染以及口腔黏膜和皮肤损伤的管理措施。
