Holopigian K, Blake R, Greenwald M J
Vision Res. 1986;26(4):621-30. doi: 10.1016/0042-6989(86)90010-6.
Human anisometropic amblyopes typically exhibit reduced contrast sensitivity in the amblyopic eye, especially at higher spatial frequencies. We determined whether this spatial frequency selective loss in contrast sensitivity is accompanied by selective losses in binocular function. Binocular summation (the improvement in one eye's detection performance produced by a subthreshold pattern presented to the fellow eye) was measured at several spatial frequencies. Normal observers exhibited equivalent binouclar summation at all spatial frequencies, whereas all anisometropic amblyopes exhibited normal summation at low spatial frequencies but none at high spatial frequencies. Stereoacuity (minimum resolvable disparity) was also measured as a function of spatial frequency. For normal observers, stereoacuity was best at the highest spatial frequency; for anisometropes stereoacuity was normal at low spatial frequencies, subnormal at intermediate spatial frequencies, and unmeasurable at higher spatial frequencies. Anisometropia may represent a form of selective binocular deprivation that affects neural mechanisms underlying binocular summation and stereopsis.
人类屈光参差性弱视患者的弱视眼通常表现出对比敏感度降低，尤其是在较高空间频率时。我们确定了这种对比敏感度的空间频率选择性损失是否伴随着双眼视功能的选择性损失。在几个空间频率下测量了双眼总和（由呈现给对侧眼的阈下图案所产生的一只眼检测性能的改善）。正常观察者在所有空间频率下均表现出同等的双眼总和，而所有屈光参差性弱视患者在低空间频率下表现出正常总和，但在高空间频率下则无。立体视锐度（最小可分辨视差）也作为空间频率的函数进行了测量。对于正常观察者，立体视锐度在最高空间频率时最佳；对于屈光参差者，立体视锐度在低空间频率时正常，在中等空间频率时低于正常，在较高空间频率时无法测量。屈光参差可能代表一种选择性双眼剥夺形式，影响双眼总和及立体视的神经机制。
