新生儿重症监护病房中晚期早产儿的发病趋势。
Trends in morbidities of late preterm infants in the neonatal intensive care unit.
机构信息
Department of Pediatrics, Duke University, Durham, NC, USA.
Duke School of Nursing, Duke University, Durham, NC, USA.
出版信息
J Perinatol. 2023 Nov;43(11):1379-1384. doi: 10.1038/s41372-023-01705-5. Epub 2023 Jul 1.
OBJECTIVE
To characterize demographics and trends in length of stay (LOS), morbidities, and mortality in late preterm infants.
STUDY DESIGN
Cohort study of infants born between 34 and 36 weeks gestation between 1999 and 2018 without major congenital anomalies at Pediatrix Medical Group neonatal intensive care units (NICUs).
RESULTS
307,967 infants from 410 NICUs met inclusion criteria. The median (25-75 percentile) LOS was 11 (8-16) days in the entire period. Postmenstrual age (PMA) at discharge increased during the cohort for all gestational ages (p < 0.001). There was a decrease in invasive ventilation, receipt of phototherapy, and reflux medications observed (p < 0.001).
CONCLUSION
In this large cohort, given 20 years of time for medical advancement, there was no significant improvement in the LOS of late preterm infants. All infants had an increased PMA at discharge, despite multiple practice changes that were observed.
目的
描述晚期早产儿的人口统计学特征和住院时间（LOS）、发病率和死亡率的趋势。
研究设计
这是一项对 1999 年至 2018 年期间在 Pediatrix 医疗集团新生儿重症监护病房（NICU）出生且无重大先天性异常的 34 至 36 周龄早产儿的队列研究。
结果
共有来自 410 个 NICU 的 307967 名婴儿符合纳入标准。在整个研究期间，中位数（25-75 百分位）的 LOS 为 11（8-16）天。对于所有胎龄，出院时的校正胎龄（PMA）在整个队列中都有所增加（p<0.001）。观察到侵入性通气、光疗和反流药物的使用减少（p<0.001）。
结论
在这个大型队列中，考虑到 20 年来医学的进步，晚期早产儿的 LOS 没有显著改善。尽管观察到了多项实践改变，但所有婴儿的出院 PMA 都有所增加。
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