褪黑素补充剂可改善风湿性疾病活动：系统评价。

Melatonin supplementation improves rheumatological disease activity: A systematic review.

机构信息

Núcleo de Pesquisa Em Doenças Crônicas Não Transmissíveis (NUPEN), School of Nutrition from the Federal University of Bahia, Salvador, Bahia, Brazil.

Serviço de Reumatologia, Hospital Universitário Evangélico Mackenzie, Curitiba, PR, Brazil.

出版信息

Clin Nutr ESPEN. 2023 Jun;55:414-419. doi: 10.1016/j.clnesp.2023.04.011. Epub 2023 Apr 20.

DOI:10.1016/j.clnesp.2023.04.011

PMID:37202076

Abstract

BACKGROUND

Melatonin is a pineal hormone with a complex role. It is linked to sleep, inflammatory, oxidative, and immunological processes.

AIM

To review the use of melatonin supplementation in rheumatological diseases.

METHODS

A systematic search of PubMed, Embase, and Scielo databases was performed, looking for articles on Melatonin and rheumatic diseases published between 1966 and August 2022.

RESULTS

Thirteen articles were identified: in fibromyalgia (n = 5 articles), rheumatoid arthritis (n = 2), systemic sclerosis (n = 1), systemic lupus erythematosus (n = 1) and osteoporosis/osteopenia (n = 3) and osteoarthritis (n = 1). There were positive results of melatonin administration in fibromyalgia, osteoarthritis, and osteoporosis/osteopenia but not in rheumatoid arthritis and lupus. The drug was well tolerated with mild side effects.

CONCLUSION

This review shows the efficacy of Melatonin in some rheumatic diseases. However, new studies are needed to elucidate the real role of this treatment in rheumatology.

摘要

背景

褪黑素是一种松果腺激素，具有复杂的作用。它与睡眠、炎症、氧化和免疫过程有关。

目的

综述褪黑素补充剂在风湿性疾病中的应用。

方法

对 PubMed、Embase 和 Scielo 数据库进行系统检索，查找 1966 年至 2022 年 8 月期间发表的关于褪黑素和风湿性疾病的文章。

结果

共确定了 13 篇文章：在纤维肌痛症（n=5 篇）、类风湿关节炎（n=2）、系统性硬化症（n=1）、系统性红斑狼疮（n=1）和骨质疏松症/骨量减少症（n=3）和骨关节炎（n=1）中。褪黑素给药在纤维肌痛症、骨关节炎和骨质疏松症/骨量减少症中有积极的结果，但在类风湿关节炎和狼疮中没有。该药物耐受性良好，仅有轻微的副作用。