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单神经元记录在理解体温调节方面有用吗?

Are single-unit recordings useful in understanding thermoregulation?

作者信息

Hellon R F

出版信息

Yale J Biol Med. 1986 Mar-Apr;59(2):197-203.

PMID:3739376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2590131/
Abstract

The data which have emerged from single-unit recordings of thermally sensitive neurons in the hypothalamus are reviewed. Although these neurons may be important components in the central control of body temperature, the interpretation of the data is fraught with uncertainties. The neurons in question could be primary thermosensors or part of an integrative network. There is a notable lack of control data to show that thermosensitivity is peculiar to the hypothalamus. Examples are given to show how the single-unit recording technique can be used successfully for tracing thermal information passing centrally from the skin.

摘要

本文综述了从下丘脑热敏神经元单单位记录中得出的数据。尽管这些神经元可能是体温中枢控制的重要组成部分,但对这些数据的解释充满了不确定性。所讨论的神经元可能是主要的温度传感器,也可能是整合网络的一部分。明显缺乏对照数据来表明热敏性是下丘脑所特有的。文中给出了一些例子,展示了单单位记录技术如何成功用于追踪从皮肤传入中枢的热信息。

相似文献

1
Are single-unit recordings useful in understanding thermoregulation?单神经元记录在理解体温调节方面有用吗?
Yale J Biol Med. 1986 Mar-Apr;59(2):197-203.
2
[The "thermoresponsive" neurons of the thermoregulation center and their functional characteristics].[体温调节中枢的“温度敏感”神经元及其功能特性]
Biull Eksp Biol Med. 1993 Jul;116(7):11-3.
3
Anterior and posterior hypothalamus: effects of independent temperature displacements on heat production in conscious goats.下丘脑前部和后部:清醒山羊中独立温度变化对产热的影响。
Pflugers Arch. 1978 Jan 31;373(1):59-68. doi: 10.1007/BF00581150.
4
[Determination of the neuronal reactions of the thermoregulation center in the posterior hypothalamus of the rabbit to thermal stimulation].[家兔下丘脑后部体温调节中枢对热刺激的神经元反应的测定]
Neirofiziologiia. 1988;20(3):291-301.
5
Effects of anterior and posterior hypothalamic temperature changes on thermoregulation in the rat.下丘脑前部和后部温度变化对大鼠体温调节的影响。
Physiol Behav. 1986;36(6):1099-1103. doi: 10.1016/0031-9384(86)90486-5.
6
[Temperature changes in various structures of the rabbit brain in response to local temperature action on the region of the anterior and posterior hypothalamus and the rostral parts of the reticular formation].[兔脑不同结构对下丘脑前部和后部以及网状结构头端区域局部温度作用的温度变化]
Patol Fiziol Eksp Ter. 1977 Jul-Aug(4):76-9.
7
[Effect of a change in the temperature of the midbrain and skin on the activity of posterior hypothalamic neurons].[中脑和皮肤温度变化对下丘脑后部神经元活动的影响]
Fiziol Zh SSSR Im I M Sechenova. 1977 Aug;63(8):1096-1101.
8
[Microelectrophysiologic analysis of the representation of different groups of afferent splanchnic nerve fibers in structures of the posterior and anterior hypothalamus in the cat].[猫后下丘脑和前下丘脑结构中不同传入内脏神经纤维群代表区的微电生理分析]
Neirofiziologiia. 1982;14(5):453-61.
9
Neuronal activities related to thermoregulation.与体温调节相关的神经元活动。
Yale J Biol Med. 1986 Mar-Apr;59(2):189-95.
10
In vitro thermosensitivity of the midline thalamus.
Brain Res. 1995 Jul 17;686(1):17-22. doi: 10.1016/0006-8993(95)00428-s.

引用本文的文献

1
Regulation of Body Temperature by the Nervous System.神经系统对体温的调节。
Neuron. 2018 Apr 4;98(1):31-48. doi: 10.1016/j.neuron.2018.02.022.
2
Cellular populations and thermosensing mechanisms of the hypothalamic thermoregulatory center.下丘脑体温调节中枢的细胞群体和热敏机制。
Pflugers Arch. 2018 May;470(5):809-822. doi: 10.1007/s00424-017-2101-0. Epub 2018 Jan 27.
3
Warm-Sensitive Neurons that Control Body Temperature.控制体温的热敏神经元。
Cell. 2016 Sep 22;167(1):47-59.e15. doi: 10.1016/j.cell.2016.08.028. Epub 2016 Sep 8.

本文引用的文献

1
Tungsten Microelectrode for Recording from Single Units.用于单细胞记录的钨微电极。
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2
TEMPERATURE-SENSITIVE NEURONES IN THE DOG'S HYPOTHALAMUS.狗下丘脑的温度敏感神经元。
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3
Thermoregulatory noradrenergic and serotonergic pathways to hypothalamic units.通往下丘脑神经元的体温调节去甲肾上腺素能和5-羟色胺能通路。
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Effects of CNS temperature on generation and transmission of temperature signals in homeotherms. A common concept for mammalian and avian thermoregulation.中枢神经系统温度对恒温动物温度信号产生和传递的影响。哺乳动物和鸟类体温调节的一个常见概念。
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Inhibitory controls on thermal neurones in the spinal trigeminal nucleus of cats and rats.
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Effect of synaptic blockade on thermosensitive neurons in hypothalamic tissue slices.突触阻断对下丘脑组织切片中热敏神经元的影响。
Am J Physiol. 1982 Nov;243(5):R480-90. doi: 10.1152/ajpregu.1982.243.5.R480.
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An analysis of a thermal afferent pathway in the rat.大鼠热传入通路的分析
J Physiol. 1982 May;326:319-28. doi: 10.1113/jphysiol.1982.sp014195.
8
Thermosensitive single-unit activity of in vitro hypothalamic slices.体外下丘脑切片的热敏单单位活动
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9
Evidence for peripheral, but not central modulation of trigeminal cold receptive cells in the rat.大鼠三叉神经冷感受细胞外周而非中枢调节的证据。
Brain Res. 1984 Jun 3;301(2):299-305. doi: 10.1016/0006-8993(84)91099-0.
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Facial sensitivity to rates of temperature change: neurophysiological and psychophysical evidence from cats and humans.面部对温度变化速率的敏感性:来自猫和人类的神经生理学及心理物理学证据。
J Physiol. 1983 Nov;344:161-75. doi: 10.1113/jphysiol.1983.sp014931.