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大鼠三叉神经冷感受细胞外周而非中枢调节的证据。

Evidence for peripheral, but not central modulation of trigeminal cold receptive cells in the rat.

作者信息

Davies S N

出版信息

Brain Res. 1984 Jun 3;301(2):299-305. doi: 10.1016/0006-8993(84)91099-0.

DOI:10.1016/0006-8993(84)91099-0
PMID:6733494
Abstract

The effects of locus coeruleus (LC), periaqueductal grey (PAG) and segmental stimulation (all of which are known to inhibit convergent nociceptive cells), were tested on the activity of cold receptive cells in the trigeminal system of the rat. LC and PAG stimulation from sites which inhibited convergent nociceptive cells had no effect on cells with cold receptive input in the trigeminal nucleus caudalis. Electrical or mechanical segmental stimulation caused suppression of activity in cold receptive trigeminal nucleus neurons. Recording from the trigeminal ganglion showed this suppression to be a property of the primary afferent cold receptors themselves and therefore it is not analogous to the proposed mechanism for the segmental inhibition of convergent nociceptive neurons.

摘要

对大鼠三叉神经系统中冷感受细胞的活性进行了测试,观察蓝斑(LC)、导水管周围灰质(PAG)和节段性刺激(已知这些均可抑制会聚性伤害感受细胞)的作用。从抑制会聚性伤害感受细胞的部位刺激LC和PAG,对三叉神经尾侧核中具有冷感受输入的细胞没有影响。电刺激或机械性节段性刺激可导致三叉神经冷感受神经元的活动受到抑制。对三叉神经节的记录显示,这种抑制是初级传入冷感受器自身的特性,因此它与所提出的节段性抑制会聚性伤害感受神经元的机制不同。

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