Centro de Estudos do Ambiente e do Mar (CESAM), Universidade De Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Departamento De Biologia, Universidade De Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
Centro de Estudos do Ambiente e do Mar (CESAM), Universidade De Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Departamento De Biologia, Universidade De Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
Environ Toxicol Pharmacol. 2023 Sep;102:104200. doi: 10.1016/j.etap.2023.104200. Epub 2023 Jun 30.
SARS-CoV-2 outbreak led to an increased marketing of disinfectants, creating a potential environmental problem. For instance, pre-pandemic environmental levels of the disinfectant benzalkonium chloride (BAC) ranging from 0.5 to 5 mgL in effluents were expected to further increase threatening aquatic life. Our aim was to characterize potential adverse effects after an acute exposure of zebrafish to different concentrations of BAC. An increase in the overall swimming activity, thigmotaxis behavior, and erratic movements were observed. An increase in CYP1A1 and catalase activities, but inhibitions of CY1A2, GSTs and GPx activities were also noticed. BAC is metabolized by CYP1A1, increasing the production of HO, thereby activating the antioxidant enzyme CAT. Data also showed an increase of AChE activity. Our study highlights adverse embryonic, behavioral, and metabolic effects of noteworthy environmental significance, especially considering that the use and release of BAC is most likely to increase in a near future.
SARS-CoV-2 爆发导致消毒剂的市场需求增加，这可能会造成环境问题。例如，在大流行之前，环境中苄索氯铵（BAC）的水平预计将从废水中的 0.5 到 5mg/L 进一步增加，这将对水生生物构成威胁。我们的目的是研究斑马鱼在急性暴露于不同浓度 BAC 后可能产生的不良影响。结果观察到整体游泳活动、触壁行为和不规则运动增加。还观察到 CYP1A1 和过氧化氢酶活性增加，而 CYP1A2、GSTs 和 GPx 活性受到抑制。BAC 由 CYP1A1 代谢，从而增加 HO 的产生，从而激活抗氧化酶 CAT。数据还显示 AChE 活性增加。我们的研究强调了具有显著环境意义的胚胎、行为和代谢不良影响，特别是考虑到 BAC 的使用和释放很可能在不久的将来增加。
