Pourshaban-Shahrestani Ali, Rezazadeh Ali, Hassan Jalal
Division of Toxicology, Department of Comparative Bioscience, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Toxicol Rep. 2025 Mar 5;14:101980. doi: 10.1016/j.toxrep.2025.101980. eCollection 2025 Jun.
The utilization of biocides in a myriad of products has become a widespread and critical practice in recent years. Among these, quaternary ammonium compounds, polyhexamethylene, parabens, and triclosan are notably prevalent across various industrial applications. However, the incorporation of these biocides raises significant concerns regarding their toxicological profile. Not only do these chemicals pose potential risks to consumers using biocide-containing products, but their environmental discharge also represents a substantial threat to the biosphere. In our meticulous review, we examined approximately 150 articles from esteemed databases including PubMed, MDPI, and Google Scholar, ultimately utilizing at least 88 of these articles to inform our analysis. Our investigation encompassed studies that probe general toxicity, behavioral toxicity, cardiovascular toxicity, and genotoxicity, among other toxicological impacts. With this comprehensive approach, we explore the zebrafish (Danio rerio) as a prominent model organism in toxicology research. This review article aims to synthesize research employing zebrafish to evaluate biocide toxicity and ascertain the suitability of this model for comprehensive analysis of biocidal agents and their associated products.
近年来，在众多产品中使用杀生剂已成为一种广泛且关键的做法。其中，季铵化合物、聚六亚甲基胍、对羟基苯甲酸酯和三氯生在各种工业应用中尤为普遍。然而，这些杀生剂的加入引发了对其毒理学特征的重大担忧。这些化学物质不仅对使用含杀生剂产品的消费者构成潜在风险，而且它们向环境中的排放也对生物圈构成了重大威胁。在我们细致的综述中，我们查阅了来自诸如PubMed、MDPI和谷歌学术等知名数据库的约150篇文章，最终利用其中至少88篇文章为我们的分析提供信息。我们的调查涵盖了探究一般毒性、行为毒性、心血管毒性和遗传毒性等其他毒理学影响的研究。通过这种全面的方法，我们将斑马鱼（Danio rerio）作为毒理学研究中一种重要的模式生物进行探讨。这篇综述文章旨在综合利用斑马鱼评估杀生剂毒性的研究，并确定该模型对于全面分析杀生剂及其相关产品的适用性。
