Masuda Takahiro
Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University.
Nihon Yakurigaku Zasshi. 2023;158(4):308-311. doi: 10.1254/fpj.22152.
The central nervous system (CNS) is a highly complex collection of various cell-types, such as neurons, glial cells, vascular cells, and immune cells, and their complex and dynamic interactions enable to achieve highly sophisticated functions of the CNS. Among such CNS cells are microglia, which are well-known primary CNS macrophages localized in the CNS parenchyma and play a pivotal role in the maintenance of tissue homeostasis. Besides microglia, there are anatomically distinct macrophage populations at the border of the CNS, such as meninge, and perivascular space, called CNS-associated macrophages (CAMs). Recent studies have given novel insights into the nature of CAMs. In this review, I will discuss our current knowledge of the origins, the cellular properties of CNS macrophages.
中枢神经系统（CNS）是由各种细胞类型高度复杂地集合而成，如神经元、胶质细胞、血管细胞和免疫细胞，它们复杂而动态的相互作用使中枢神经系统能够实现高度复杂的功能。在这些中枢神经系统细胞中，小胶质细胞是众所周知的主要中枢神经系统巨噬细胞，位于中枢神经系统实质内，在维持组织内环境稳定方面发挥着关键作用。除了小胶质细胞，在中枢神经系统边界，如脑膜和血管周围间隙，存在解剖学上不同的巨噬细胞群体，称为中枢神经系统相关巨噬细胞（CAMs）。最近的研究对中枢神经系统相关巨噬细胞的性质有了新的见解。在这篇综述中，我将讨论我们目前对中枢神经系统巨噬细胞的起源和细胞特性的认识。
