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中枢神经系统巨噬细胞亚群的起源和发展的新见解。

Novel insights into the origin and development of CNS macrophage subsets.

机构信息

Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

出版信息

Clin Transl Med. 2022 Nov;12(11):e1096. doi: 10.1002/ctm2.1096.

DOI:10.1002/ctm2.1096
PMID:36336786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9637656/
Abstract

The central nervous system (CNS) hosts a variety of immune cells, including two distinct macrophage populations: microglia are found in the parenchyma, whereas CNS-associated macrophages (CAMs) cover the CNS interfaces, such as the perivascular spaces, the meninges and the choroid plexus. Recent studies have given novel insights into the nature of CAMs as compared to microglia. In this mini-review, we summarise the current knowledge about the ontogenetic relationship and the underlying mechanism for the establishment of CNS macrophages during development.

摘要

中枢神经系统 (CNS) 内存在多种免疫细胞，包括两种截然不同的巨噬细胞群体：小胶质细胞存在于实质中，而中枢神经系统相关巨噬细胞 (CAMs) 则覆盖 CNS 的界面，如血管周围间隙、脑膜和脉络丛。最近的研究对 CAMs 与小胶质细胞的性质有了新的认识。在这篇迷你综述中，我们总结了目前关于发育过程中中枢神经系统巨噬细胞的发生关系和建立的潜在机制的知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c03f/9637656/0084c892539d/CTM2-12-e1096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c03f/9637656/dec4868a8e49/CTM2-12-e1096-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c03f/9637656/beb7a6d5cbdc/CTM2-12-e1096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c03f/9637656/0084c892539d/CTM2-12-e1096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c03f/9637656/dec4868a8e49/CTM2-12-e1096-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c03f/9637656/beb7a6d5cbdc/CTM2-12-e1096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c03f/9637656/0084c892539d/CTM2-12-e1096-g002.jpg

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A spinal microglia population involved in remitting and relapsing neuropathic pain.参与缓解和复发性神经病理性疼痛的脊髓小胶质细胞群体。
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A map of transcriptional heterogeneity and regulatory variation in human microglia.人类小胶质细胞转录异质性和调控变异的图谱。
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