昼夜节律皮肤温度节律与真实环境中活动记录仪睡眠测量的关联。

Association between circadian skin temperature rhythms and actigraphic sleep measures in real-life settings.

机构信息

Department of Epidemiology, Nara Medical University School of Medicine, Nara, Japan.

出版信息

J Clin Sleep Med. 2023 Jul 1;19(7):1281-1292. doi: 10.5664/jcsm.10590.

DOI:10.5664/jcsm.10590

PMID:37394793

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10315598/

Abstract

STUDY OBJECTIVES

Skin temperature manipulation with little or no change in core body temperature affects sleep-wake states; however, the association of 24-hour skin temperature variation with sleep quality has not been investigated in a large-scale population. We examined the association between the circadian rhythm of distal skin temperature and sleep quality in real-life settings and aimed to provide additional evidence of the link between thermoregulation and sleep-wake states.

METHODS

In this cross-sectional study of 2,187 community-dwelling adults, we measured distal skin temperature at the ventral forearm at 3-minute intervals for 7 consecutive days to calculate nonparametric indicators of a circadian skin temperature rhythm, including intradaily variability, interdaily stability, and relative amplitude. Participants underwent simultaneous 7-day wrist actigraphy to objectively measure sleep quality. The association between nonparametric circadian skin temperature rhythm indicators and 7-day sleep measures was evaluated using multivariable linear regression models.

RESULTS

Lower intradaily variability and higher interdaily stability and relative amplitude of distal skin temperature were significantly associated with higher sleep efficiency, shorter wake after sleep onset, and longer total sleep time (all < .001). After adjusting for demographic, clinical, and environmental factors, the coefficients for the linear trend of sleep efficiency were -1.20 (95% confidence interval: -1.53, -0.87), 1.08 (95% confidence interval: 0.80-1.36), and 1.47 (95% confidence interval: 1.04-1.89) per quartile increase in intradaily variability, interdaily stability, and relative amplitude, respectively (all < .001).

CONCLUSIONS

Distal skin temperature with lower fluctuations and higher regularity and rhythm amplitudes was associated with better sleep quality. Our results could be applied in chronobiological interventions to improve sleep quality.

CITATION

Tai Y, Obayashi K, Yamagami Y, Saeki K. Association between circadian skin temperature rhythms and actigraphic sleep measures in real-life settings. . 2023;19(7):1281-1292.

摘要

研究目的

皮肤温度的变化对核心体温的影响很小或没有，但 24 小时皮肤温度变化与睡眠质量的关联尚未在大规模人群中进行研究。我们在真实环境中检查了远端皮肤温度的昼夜节律与睡眠质量之间的关系，并旨在提供体温调节与睡眠-觉醒状态之间联系的额外证据。

方法

在这项针对 2187 名社区居住成年人的横断面研究中，我们在连续 7 天内每隔 3 分钟测量前臂腹侧的远端皮肤温度，以计算昼夜皮肤温度节律的非参数指标，包括日内变异性、日间稳定性和相对幅度。参与者同时接受 7 天腕部活动记录仪测量以客观评估睡眠质量。使用多变量线性回归模型评估非参数昼夜皮肤温度节律指标与 7 天睡眠测量之间的关联。

结果

较低的日内变异性、较高的日间稳定性和相对幅度与更高的睡眠效率、较短的睡眠潜伏期后醒来时间和更长的总睡眠时间显著相关（均 <.001）。在校正人口统计学、临床和环境因素后，睡眠效率的线性趋势系数分别为-1.20（95%置信区间：-1.53，-0.87）、1.08（95%置信区间：0.80-1.36）和 1.47（95%置信区间：1.04-1.89），每四分位间距增加一个单位（均 <.001）。