Wang Liping, Chen Zhe, Liu Guohong, Pan Yunbao
Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.
Department of Otolaryngology Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.
Genes Dis. 2022 Aug 6;10(3):990-1004. doi: 10.1016/j.gendis.2022.07.009. eCollection 2023 May.
Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth. This study reviewed the biological properties of NK cells, the dynamic phenotypic changes of NK cells in the TME, and the communication between NK cells and other immune and nonimmune cells.
自然杀伤（NK）细胞可清除多种肿瘤细胞和异常细胞。然而，肿瘤微环境（TME）中的NK细胞功能往往会耗竭。甚至有少数NK细胞亚群会促进肿瘤生长。本研究综述了NK细胞的生物学特性、TME中NK细胞的动态表型变化，以及NK细胞与其他免疫和非免疫细胞之间的相互作用。
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