Department of Geriatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
Clin Interv Aging. 2023 Jun 27;18:999-1007. doi: 10.2147/CIA.S409140. eCollection 2023.
Determine the relationship of renal function with frailty using different formulas for estimated glomerular filtration rate (eGFR).
Individuals who were 60-years-old or more (n=507) were recruited from August 2020 to June 2021, and the FRAIL scale was used to classify them as non-frail or frail. The three equations used to compute the eGFR were based on serum creatinine (eGFRcr), cystatin C (eGFRcys), or SCr+CysC (eGFRcr-cys). Renal function was classified using eGFR and defined as normal (≥90 mL/min/1.73m), mild damage (59-89 mL/min/1.73m), or moderate damage (≤60 mL/min/1.73m). The relationship of frailty with renal function was analyzed. A subset of participants (n=358) was used to analyze changes in eGFR from 1 January 2012 to 31 December 2021 according to frailty and using the different eGFR equations.
There were significant differences between the eGFRcr-cys and eGFRcr values in the frail group (<0.05), but not the non-frail group; however, the differences between the eGFRcr-cys and eGFRcys values were significant in the frail and non-frail groups (<0.001). Based on each eGFR equation, the prevalence of frailty increased as eGFR decreased (<0.001), but there was no significant relationship after adjusting for age or the age-adjusted Charlson co-morbidity index. There were temporal declines in eGFR in all three frailty groups (robust, pre-frail, and frail), especially in the frail group (2.226 mL/min/1.73m per year; <0.001).
For older individuals who are frail, the eGFRcr value may not provide accurate estimates of renal function. Frailty is associated with a rapid decline in kidney function.
使用不同的估算肾小球滤过率（eGFR）公式来确定肾功能与虚弱之间的关系。
从 2020 年 8 月至 2021 年 6 月招募了 507 名 60 岁及以上的个体，并使用 FRAIL 量表将他们分为非虚弱或虚弱。用于计算 eGFR 的三个方程基于血清肌酐（eGFRcr）、胱抑素 C（eGFRcys）或 SCr+CysC（eGFRcr-cys）。使用 eGFR 将肾功能分类，定义为正常（≥90 mL/min/1.73m）、轻度损伤（59-89 mL/min/1.73m）或中度损伤（≤60 mL/min/1.73m）。分析虚弱与肾功能之间的关系。使用不同的 eGFR 方程，对从 2012 年 1 月 1 日至 2021 年 12 月 31 日期间的 358 名参与者的肾功能进行了亚组分析。
虚弱组的 eGFRcr-cys 和 eGFRcr 值之间存在显著差异（<0.05），而非虚弱组则没有；然而，虚弱组和非虚弱组的 eGFRcr-cys 和 eGFRcys 值之间存在显著差异（<0.001）。基于每个 eGFR 方程，随着 eGFR 的降低，虚弱的患病率增加（<0.001），但在调整年龄或年龄调整后的 Charlson 合并症指数后，两者之间没有显著关系。所有三个虚弱组（强壮、虚弱前期和虚弱）的 eGFR 都呈时间下降趋势，尤其是在虚弱组中（每年 2.226 mL/min/1.73m；<0.001）。
对于虚弱的老年人，eGFRcr 值可能无法准确估计肾功能。虚弱与肾功能的快速下降有关。
