Melén I, Andréasson L, Ivarsson A, Jannert M, Johansson C J
Acta Otolaryngol. 1986 Jul-Aug;102(1-2):99-105. doi: 10.3109/00016488609108652.
Ostial airway resistance (OAR) of 11 maxillary ostia and the airway resistance of the nasal cavity (NAR) in 6 healthy persons were tested before and after administration of phenylpropanolamine (Ppa) and placebo. The effects of physical exercise were also tested. After logarithmic transformation, the resistance values showed a normal distribution. Significant effects on the ostial resistance in relation to initial values were found after Ppa medication. The effect was more pronounced in recumbency than in the sitting position. Physical exercise also gave a significant reduction of ostial resistance while placebo treatment was without effect. On comparison of the Ppa- and placebo-groups in an extended statistical analysis, more striking differences were found both for OAR and NAR. In this model study, Ppa thus showed effects in healthy individuals.
在6名健康受试者中，于服用去氧肾上腺素（Ppa）和安慰剂前后，分别测试了11个上颌窦口的窦口气道阻力（OAR）以及鼻腔气道阻力（NAR）。同时也测试了体育锻炼的影响。经对数转换后，阻力值呈正态分布。服用Ppa药物后，与初始值相比，窦口阻力有显著变化。卧位时的效果比坐位时更明显。体育锻炼也能显著降低窦口阻力，而安慰剂治疗则无效果。在扩展的统计分析中比较Ppa组和安慰剂组时，发现OAR和NAR均存在更显著的差异。因此，在这个模型研究中，Ppa对健康个体显示出了作用。
