Bende M, Andersson K E, Johansson C J, Sjögren C, Svensson G
Acta Otolaryngol. 1984 Nov-Dec;98(5-6):543-7. doi: 10.3109/00016488409107595.
By means of anterior rhinomanometry, the decongestant effect of topically applied phenylpropanolamine (PPA) was evaluated in 40 patients with nasal obstruction. A dose-response relation was obtained for 0.5, 2.5 and 5.0% PPA solution, with the maximum effect (40% decongestion) found with the 2.5% solution. The decongestant effect was comparable to that induced by physical exercise (50% decongestion). It is concluded that PPA nose-drops are effective and offer an attractive alternative to some of the commonly used nasal decongestants.
通过前鼻测压法，对40例鼻塞患者局部应用苯丙醇胺（PPA）的减充血效果进行了评估。获得了0.5%、2.5%和5.0%PPA溶液的剂量反应关系，2.5%溶液产生的效果最佳（鼻充血减轻40%）。其减充血效果与体育锻炼所产生的效果相当（鼻充血减轻50%）。得出的结论是，PPA滴鼻剂有效，为一些常用的鼻减充血剂提供了有吸引力的替代选择。
