Flora S J, Tandon S K
Acta Pharmacol Toxicol (Copenh). 1986 May;58(5):374-8. doi: 10.1111/j.1600-0773.1986.tb00124.x.
Thiamine, ascorbic acid and their combination were investigated for their ability to prevent or treat the experimental lead intoxication in rats. The combination of the two vitamins was most effective in reducing the lead induced inhibition in the activity of blood delta-aminolevulinic acid dehydratase, elevation in the level of blood zinc protoporphyrin and the urinary excretion of delta-aminolevulinic acid and the uptake of lead in blood, liver and kidney. The combined treatment post lead exposure was also most effective in restoring the lead induced biochemical alterations and mobilizing lead from the tissues. The order of effectiveness was, thiamine + ascorbic acid less than ascorbic acid less than thiamine. The lead induced changes in brain biogenic amines and the brain concentration of lead remained unaffected by these vitamins.
研究了硫胺素、抗坏血酸及其组合预防或治疗大鼠实验性铅中毒的能力。两种维生素的组合在降低铅诱导的血液δ-氨基乙酰丙酸脱水酶活性抑制、血液锌原卟啉水平升高、δ-氨基乙酰丙酸的尿排泄以及血液、肝脏和肾脏中铅的摄取方面最为有效。铅暴露后联合治疗在恢复铅诱导的生化改变和从组织中动员铅方面也最有效。有效性顺序为：硫胺素+抗坏血酸＜抗坏血酸＜硫胺素。这些维生素对铅诱导的脑生物胺变化和脑中铅浓度没有影响。
