Flora S J, Kumar D, Das Gupta S
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India.
Pharmacol Toxicol. 1991 Jan;68(1):3-7. doi: 10.1111/j.1600-0773.1991.tb01199.x.
The ability of zinc, methionine or their combination given by gavage to prevent or treat experimental oral lead intoxication in rats was investigated. Simultaneous oral supplementation with zinc plus methionine was found to be most effective in reducing lead induced inhibition of delta-aminolevulinic acid dehydratase (ALAD) activity in blood, elevation of urinary delta-aminolevulinic acid (ALA) excretion and in enhancing the hepatic glutathione (GSH) contents. The combination was also most effective in reducing the accumulation of lead in blood, liver and kidney compared to zinc or methionine alone. Prevention was more effective than treatment after lead exposure which may be caused by a decrease in the absorption of lead in the gastrointestinal tract in the presence of zinc and/or methionine.
研究了通过灌胃给予锌、蛋氨酸或其组合预防或治疗大鼠实验性口服铅中毒的能力。发现同时口服补充锌加蛋氨酸在降低铅诱导的血液中δ-氨基乙酰丙酸脱水酶（ALAD）活性抑制、尿中δ-氨基乙酰丙酸（ALA）排泄升高以及提高肝脏谷胱甘肽（GSH）含量方面最有效。与单独使用锌或蛋氨酸相比，该组合在减少血液、肝脏和肾脏中铅的积累方面也最有效。铅暴露后预防比治疗更有效，这可能是由于在存在锌和/或蛋氨酸的情况下胃肠道中铅的吸收减少所致。
