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Artemisitene: a promising natural drug candidate with various biological activities needs to confirm the interactional targets.

作者信息

Lin Xian, Chen Jian

机构信息

Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, China.

Institute of Immunology and Inflammatory Diseases, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.

出版信息

Front Pharmacol. 2023 Jun 15;14:1221291. doi: 10.3389/fphar.2023.1221291. eCollection 2023.

DOI:10.3389/fphar.2023.1221291
PMID:37397487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10308078/
Abstract
摘要

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Artemisitene: a promising natural drug candidate with various biological activities needs to confirm the interactional targets.青蒿素：一种具有多种生物活性的有前景的天然药物候选物，需要确认其相互作用靶点。
Front Pharmacol. 2023 Jun 15;14:1221291. doi: 10.3389/fphar.2023.1221291. eCollection 2023.
2
Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis.源自青蒿素的青蒿烯阻断活性氧介导的NLRP3炎性小体并减轻溃疡性结肠炎。
Int Immunopharmacol. 2022 Dec;113(Pt B):109431. doi: 10.1016/j.intimp.2022.109431. Epub 2022 Nov 13.
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Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury.青蒿素激活Nrf2依赖的抗氧化反应并预防博来霉素诱导的肺损伤。
FASEB J. 2016 Jul;30(7):2500-10. doi: 10.1096/fj.201500109R. Epub 2016 Mar 22.
4
Determination of artemisitene in rat plasma by ultra-performance liquid chromatography/tandem mass spectrometry and its application in pharmacokinetics.
Rapid Commun Mass Spectrom. 2017 Jul 15;31(13):1121-1128. doi: 10.1002/rcm.7881.
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A towards-multidimensional screening approach to predict candidate genes of rheumatoid arthritis based on SNP, structural and functional annotations.基于 SNP、结构和功能注释的类风湿关节炎候选基因的多维筛选方法。
BMC Med Genomics. 2010 Aug 20;3:38. doi: 10.1186/1755-8794-3-38.
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Microbial metabolism of artemisitene.青蒿烯的微生物代谢
Phytochemistry. 1999 May;51(2):257-61. doi: 10.1016/s0031-9422(98)00770-5.
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Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway.青蒿素通过调控 c-Myc-拓扑异构酶通路诱导 DNA 损伤抑制肿瘤发生。
Oncogene. 2018 Sep;37(37):5079-5087. doi: 10.1038/s41388-018-0331-z. Epub 2018 May 24.
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Periodontal Disease as a Risk Factor for Rheumatoid Arthritis: A Systematic Review.牙周病作为类风湿关节炎的一个风险因素：一项系统综述。
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C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene.C-16青蒿素衍生物及其抗疟和细胞毒性活性：通过对青蒿烯进行亲核加成合成青蒿素单体、二聚体、三聚体和四聚体
J Med Chem. 2001 Dec 20;44(26):4688-95. doi: 10.1021/jm0103007.
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Conversion of artemisinin (qinghaosu) to iso-artemisitene and to 9-epi-artemisinin1.将青蒿素（qinghaosu）转化为异青蒿素（iso-artemisitene）和 9-表青蒿素 1。
Planta Med. 1987 Jun;53(3):266-8. doi: 10.1055/s-2006-962700.

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DNA and RNA Methylation in Rheumatoid Arthritis-A Narrative Review.类风湿关节炎中的DNA和RNA甲基化——一篇综述
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本文引用的文献

1
Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes.青蒿素通过调节成纤维样滑膜细胞中 METTL3 介导的 ICAM2 mRNA 的 N6-甲基腺苷修饰来抑制类风湿关节炎的进展。
Clin Transl Med. 2022 Dec;12(12):e1148. doi: 10.1002/ctm2.1148.
2
Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis.源自青蒿素的青蒿烯阻断活性氧介导的NLRP3炎性小体并减轻溃疡性结肠炎。
Int Immunopharmacol. 2022 Dec;113(Pt B):109431. doi: 10.1016/j.intimp.2022.109431. Epub 2022 Nov 13.
3
Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation.半胱氨酸 151 的 KEAP1 作为青蒿素诱导 Nrf2 激活的潜在靶点。
Biomed Res Int. 2019 Oct 15;2019:5198138. doi: 10.1155/2019/5198138. eCollection 2019.
4
Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway.青蒿素通过调控 c-Myc-拓扑异构酶通路诱导 DNA 损伤抑制肿瘤发生。
Oncogene. 2018 Sep;37(37):5079-5087. doi: 10.1038/s41388-018-0331-z. Epub 2018 May 24.
5
Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury.青蒿素激活Nrf2依赖的抗氧化反应并预防博来霉素诱导的肺损伤。
FASEB J. 2016 Jul;30(7):2500-10. doi: 10.1096/fj.201500109R. Epub 2016 Mar 22.
6
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum.血红素激活青蒿素对恶性疟原虫的混杂靶向作用。
Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111.
7
The Nobel Prize in Medicine 2015: Two drugs that changed global health.2015年诺贝尔医学奖：两种改变全球健康状况的药物。
Sci Transl Med. 2015 Dec 2;7(316):316ed14. doi: 10.1126/scitranslmed.aad5868.
8
Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells.青蒿素衍生物可诱导肿瘤细胞发生铁依赖性细胞死亡（铁死亡）。
Phytomedicine. 2015 Oct 15;22(11):1045-54. doi: 10.1016/j.phymed.2015.08.002. Epub 2015 Aug 18.
9
Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin.黄花蒿次生代谢产物对癌细胞的细胞毒性活性与其指定活性成分青蒿素的比较。
Phytomedicine. 2011 Aug 15;18(11):959-69. doi: 10.1016/j.phymed.2011.06.008. Epub 2011 Aug 9.
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Artemisitene, a New Sesquiterpene Lactone Endoperoxide from Artemisia annua.青蒿素，一种来自黄花蒿的新型倍半萜内酯环氧化物。
Planta Med. 1985 Oct;51(5):441-2. doi: 10.1055/s-2007-969543.