Artemisitene: a promising natural drug candidate with various biological activities needs to confirm the interactional targets.
作者信息
Lin Xian, Chen Jian
机构信息
Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, China.
Institute of Immunology and Inflammatory Diseases, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
出版信息
Front Pharmacol. 2023 Jun 15;14:1221291. doi: 10.3389/fphar.2023.1221291. eCollection 2023.
Abstract
摘要
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Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes.青蒿素通过调节成纤维样滑膜细胞中 METTL3 介导的 ICAM2 mRNA 的 N6-甲基腺苷修饰来抑制类风湿关节炎的进展。
Clin Transl Med. 2022 Dec;12(12):e1148. doi: 10.1002/ctm2.1148.
2
Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis.源自青蒿素的青蒿烯阻断活性氧介导的NLRP3炎性小体并减轻溃疡性结肠炎。
Int Immunopharmacol. 2022 Dec;113(Pt B):109431. doi: 10.1016/j.intimp.2022.109431. Epub 2022 Nov 13.
3
Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation.半胱氨酸 151 的 KEAP1 作为青蒿素诱导 Nrf2 激活的潜在靶点。
Biomed Res Int. 2019 Oct 15;2019:5198138. doi: 10.1155/2019/5198138. eCollection 2019.
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Oncogene. 2018 Sep;37(37):5079-5087. doi: 10.1038/s41388-018-0331-z. Epub 2018 May 24.
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