Unal Betul, Celik Mennan Yigitcan, Gedik Elif Ocak, Bassorgun Cumhur Ibrahim, Elpek Gulsum Ozlem
Department of Pathology, Akdeniz University Medical School, Antalya 07070, Turkey.
World J Hepatol. 2023 Jun 27;15(6):775-785. doi: 10.4254/wjh.v15.i6.775.
Hepatocellular (HCC) and intrahepatic cholangiocarcinoma (ICC), the most common primary tumors of the liver, are among the most important causes of cancer deaths worldwide. Because patients with primary liver tumors are frequently diagnosed at an advanced stage and have high mortality, many efforts have been made to identify new markers to determine their behavior and treatment, similar to those in other solid organ tumors. Recently, morphological assessment of tumor budding (TB) has been revealed as a promising prognostic finding to predict tumor behavior and survival across several different tumor types. Currently, the TB score in colorectal cancer has been revealed as an important parameter in pathology report protocols to determine the course of the disease. Regarding the liver, despite enormous data showing that many mechanisms involved in TB are associated with tumor behavior in both HCC and ICC, studies focusing on the role of TB in predicting the behavior and prognosis of these tumors have started to be investigated very recently. The purpose of this review is to present data about TB in primary tumors of the liver, pointing out the potential role of this parameter in determining the course of the disease, and emphasize the need to increase the number of further studies focusing on the evaluation of this parameter with an overview of the mechanisms involved in TB.
肝细胞癌（HCC）和肝内胆管癌（ICC）是肝脏最常见的原发性肿瘤，也是全球癌症死亡的最重要原因之一。由于原发性肝癌患者经常在晚期被诊断出来且死亡率很高，因此人们做出了许多努力来寻找新的标志物，以确定其行为和治疗方法，这与其他实体器官肿瘤的情况类似。最近，肿瘤芽生（TB）的形态学评估已被证明是一种有前景的预后指标，可预测多种不同肿瘤类型的肿瘤行为和生存情况。目前，结直肠癌中的TB评分已被证明是病理报告方案中确定疾病进程的一个重要参数。关于肝脏，尽管大量数据表明，TB涉及的许多机制与HCC和ICC的肿瘤行为相关，但聚焦于TB在预测这些肿瘤的行为和预后中作用的研究直到最近才开始进行。这篇综述的目的是展示关于肝脏原发性肿瘤中TB的数据，指出该参数在确定疾病进程中的潜在作用，并强调需要增加更多的进一步研究，通过概述TB涉及的机制来评估该参数。
