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急性新冠相关髋关节炎。病例报告及文献综述

Acute COVID-Related Hip Arthritis. Case Report and Literature Review.

作者信息

Kalavrytinos Dimitrios, Kosmidis Ilias-Alexandros

机构信息

Department of Trauma & Orthopaedic, Mid and South Essex NHS Foundation Trust, Basildon and Thurrock University Hospital, Nether Mayne, Basildon SS165NL.

出版信息

J Orthop Case Rep. 2023 Jun;13(6):40-43. doi: 10.13107/jocr.2023.v13.i06.3688.

DOI:10.13107/jocr.2023.v13.i06.3688
PMID:37398528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10308990/
Abstract

INTRODUCTION

2 years after the SARS-CoV-2 outbreak which is responsible for the COVID-19 pandemic, the clinical presentations remain unclear and unpredictable. The disease can present with a heterogeneous clinical course and a wide spectrum of clinical manifestations which can cause various complications from different systems, including musculoskeletal.

CASE REPORT

The case of a young, fit, and healthy female patient with severe onset of hip pain which started only shortly after being tested positive for COVID-19 infection is presented in this study. There is no history of rheumatologic disease. Clinical assessment did not show any signs of erythema at the hip region, however, on palpation, there was significant tenderness at the anterior aspect of the left hip joint. The patient was unable to bare weight on this hip and could not straight leg raise, and the rotation of the hip was severely restricted due to underlying pain. The nasopharyngeal swabs for SARS-Vo2 were performed and came back positive. The CRP was 205 and plain anteroposterior radiograph of the pelvis did not show abnormalities. A diagnostic aspiration under sedation in theaters was offered; the culture and enrichment were negative for infection. Since the symptoms were not improving with conservative measures, an open washout of the joint cavity was performed in theatres. The microbiologists guided on the antibiotic treatment and adequate analgesia was prescribed. Symptoms settled very soon after the open procedure and the requirements for analgesics were reduced to minimal use. The following couple of days, the pain, range of movement, and mobility significantly improved, and the patient returned within 2 weeks back to her normal activities. The rheumatologists organized a complete screening which ruled out elements of seronegative disease. In the final, 6-month follow-up, the patient was totally symptom free, and the blood markers were entirely unremarkable.

CONCLUSION

This is the first case of COVID-19-related, hip arthritis recorded worldwide, in a patient without any predisposing factors. Clinical suspicion is the key for early diagnosis and treatment for every COVID-19-positive patient with musculoskeletal symptoms, even for the patients with no history of autoimmune diseases. Viral-related arthritis remains a diagnosis of exclusion and underlies the importance to perform all the test to rule out other possible inflammatory arthritis. Our experience showed that early irrigation of the joint cavity is related with efficient symptoms relief, less requirement for analgesia, less time in hospital, and quicker return to daily activities.

摘要

引言

导致新冠疫情的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)爆发两年后,其临床表现仍不明确且难以预测。该疾病的临床病程具有异质性,临床表现范围广泛,可引发包括肌肉骨骼系统在内的不同系统的各种并发症。

病例报告

本研究介绍了一名年轻、健康的女性患者的病例,她在新冠病毒感染检测呈阳性后不久突然出现严重的髋部疼痛。患者无风湿性疾病史。临床评估显示髋部区域无任何红斑迹象,但触诊时左髋关节前部有明显压痛。患者无法用患侧髋部承重,无法直腿抬高,且由于疼痛,髋关节活动严重受限。进行了新冠病毒鼻咽拭子检测,结果呈阳性。C反应蛋白(CRP)为205,骨盆前后位平片未显示异常。在手术室对患者进行了镇静下的诊断性穿刺抽吸;培养及富集结果显示无感染。由于保守治疗症状未改善,遂在手术室对关节腔进行了切开冲洗。微生物学家指导了抗生素治疗,并开具了适当的镇痛药物。切开手术后症状很快缓解,镇痛药物的使用需求降至最低。在接下来的几天里,疼痛、活动范围和行动能力显著改善,患者在两周内恢复了正常活动。风湿病学家进行了全面筛查,排除了血清阴性疾病的因素。在最后的6个月随访中,患者完全无症状,血液指标完全正常。

结论

这是世界上首例记录在案的与新冠病毒相关的髋关节炎病例,患者无任何诱发因素。临床怀疑是每一位有肌肉骨骼症状的新冠病毒阳性患者早期诊断和治疗的关键,即使是没有自身免疫疾病史的患者。病毒相关性关节炎仍然是一种排除性诊断,这凸显了进行所有检查以排除其他可能的炎性关节炎的重要性。我们的经验表明,早期关节腔冲洗与有效缓解症状、减少镇痛药物需求、缩短住院时间以及更快恢复日常活动有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ce/10308990/e5b929bf0bc0/JOCR-13-40-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ce/10308990/03d25950c269/JOCR-13-40-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ce/10308990/e5b929bf0bc0/JOCR-13-40-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ce/10308990/03d25950c269/JOCR-13-40-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9ce/10308990/e5b929bf0bc0/JOCR-13-40-g002.jpg

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