[氯己定缓释乳胶导尿管的疗效：首次报告：预防尿路感染的临床试验]

[Efficacy of a latex Foley catheter with sustained release of chlorhexidine: 1st report: Clinical trials for the prevention of urinary tract infection].

作者信息

Nakano H, Seko S, Sumii T, Nihira H, Fujii M, Okada K, Kitano T, Kodama M, Ohnishi Y, Okutani T

出版信息

Hinyokika Kiyo. 1986 Apr;32(4):567-74.

Abstract

Seventy five patients requiring urethral catheterization for over 24 hours were treated with a latex Foley catheter with sustained release of chlorhexidine in a closed drainage system. While the catheter was indwelling, urinary concentrations of chlorhexidine were maintained at the level of 1 to 2 micrograms/ml in average in almost all patients. The catheter was highly effective in preventing the acquisition of catheter-associated bacteriuria in patients with initially sterile urine without systemic antimicrobial therapy. The acquisition rate of bacteriuria was 8, 16, 23, 35 and 74% on day 3, 4, 5, 6 and 7 with the catheter indwelling, respectively. The catheter was not effective in eradicating preexisting bacteriuria. Complications of the catheter were minimal.

摘要

75名需要留置导尿超过24小时的患者，采用了在封闭引流系统中可持续释放洗必泰的乳胶Foley导尿管进行治疗。在导尿管留置期间，几乎所有患者尿液中洗必泰的浓度平均维持在1至2微克/毫升的水平。在未进行全身抗菌治疗的情况下，该导尿管对于预防初始尿液无菌的患者发生导尿管相关菌尿非常有效。导尿管留置第3、4、5、6和7天时，菌尿发生率分别为8%、16%、23%、35%和74%。该导尿管对于根除已存在的菌尿无效。导尿管的并发症极少。