脑脊液细胞因子水平影响阿尔茨海默病的脑电图活动。
Cerebrospinal fluid cytokine levels affect electroencephalographic activity in Alzheimer's disease.
作者信息
Bruno Matilde, Bonomi Chiara Giuseppina, Castelli Alessandro, Izzi Francesca, Placidi Fabio, Falletti Silvia, Mercuri Nicola Biagio, Motta Caterina, Martorana Alessandro
机构信息
Memory Clinic, Policlinico Tor Vergata, University of Rome "Tor Vergata" - Rome, Italy.
Epilepsy Centre, Policlinico Tor Vergata, University of Rome Tor Vergata - Rome, Italy.
出版信息
J Alzheimers Dis Rep. 2025 Mar 28;9:25424823241306772. doi: 10.1177/25424823241306772. eCollection 2025 Jan-Dec.
To investigate the role of neuroinflammation as mediator of amyloid-β-induced cortical activity changes in Alzheimer's disease (AD), we examined the relationship between cerebrospinal fluid (CSF) inflammatory cytokines (IL-1β, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, TNF-α, IFN-γ, GM-CSF, G-CSF, MIP-1α, MCP-1) and electroencephalographic (EEG) abnormalities in a cohort of biologically defined AD patients (n = 55, M:F = 19:36, median age 73, Mini-Mental State Examination ≥ 22). We retrieved a positive association between IL-4 CSF levels and EEG background activity frequency; IL-7, IL-8, and IL-12 CSF levels were positively associated with the presence of interictal epileptiform discharges. Neuroinflammation accompanying AD pathology may enhance the amyloid's epileptogenic potential while also counteracting neurodegenerative damage.
为了研究神经炎症作为阿尔茨海默病（AD）中淀粉样蛋白β诱导的皮质活动变化的介质的作用，我们在一组生物学定义明确的AD患者（n = 55，男：女 = 19：36，中位年龄73岁，简易精神状态检查表≥22）中，研究了脑脊液（CSF）炎性细胞因子（IL-1β、IL-2、IL-4、IL-6、IL-7、IL-8、IL-10、IL-12、IL-13、IL-17、TNF-α、IFN-γ、GM-CSF、G-CSF、MIP-1α、MCP-1）与脑电图（EEG）异常之间的关系。我们发现IL-4脑脊液水平与EEG背景活动频率呈正相关；IL-7、IL-8和IL-12脑脊液水平与发作间期癫痫样放电的存在呈正相关。伴随AD病理的神经炎症可能会增强淀粉样蛋白的致痫潜力，同时也会对抗神经退行性损伤。
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