合成表观遗传学辅助的微生物底盘工程。
Synthetic epigenetics-assisted microbial chassis engineering.
机构信息
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China.
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
出版信息
Trends Microbiol. 2023 Sep;31(9):889-893. doi: 10.1016/j.tim.2023.06.001. Epub 2023 Jul 1.
Microbial chassis engineering is the milestone of efficient biotechnological applications. However, microbial chassis cell engineering is adversely affected by (i) regulatory tool orthogonality, (ii) host metabolic fitness, and (iii) cell population heterogeneity. Herein, we explore how synthetic epigenetics can potentially address these limitations and offer insights into prospects in this field.
微生物底盘工程是高效生物技术应用的里程碑。然而，微生物底盘细胞工程受到（i）调控工具正交性、（ii）宿主代谢适应性和（iii）细胞群体异质性的不利影响。在此，我们探讨了合成表观遗传学如何可能解决这些限制，并为该领域的前景提供了一些见解。
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