Üniversiteler Mahallesi, Ankara City Hospital, PM&R Hospital, Ankara, Turkey.
Eur Rev Med Pharmacol Sci. 2023 Jun;27(12):5378-5389. doi: 10.26355/eurrev_202306_32772.
Gabapentinoids are gamma-aminobutyric acid analogue agents used in the treatment of neuropathic pain. They are increasingly being abused to achieve euphoric and dissociative effects. This study aimed to determine drug misuse/abuse and related factors in patients who used gabapentinoids for neuropathic pain.
This study included 140 patients over the age of 18. Patients were excluded from the study if they had aphasia, dementia, or diseases that led to aphasia or cooperative and cognitive dysfunction. They were also excluded if they lacked sufficient information about how long or at what dosage they had been using the drug. The Beck Depression Inventory and Beck Anxiety Inventory were used to evaluate depression and anxiety states. The patients' levels of drug abuse were determined according to the definitions provided in the terminology for misuse, abuse, and related events.
The mean age of the patients was 56.78 ± 14.45 years, and 52.1% of them were females. While 57.9% of the patients used pregabalin, 42.1% of the patients used gabapentin. For the median (min-max) of the dataset, the pregabalin dose was 300 (50-600) mg/day, and the gabapentin dose was 900 (300-2,400) mg/day. Abuse was present in 17.9% of the patients. Risk factors for gabapentinoid abuse were smoking, alcohol, and antidepressant use, anxiety and depression, living alone, and drug dose and duration of use.
Before prescribing drugs and managing the treatment process in a controlled manner, questioning patients about their risk factors can reduce the rate of abuse.
加巴喷丁类药物是一种γ-氨基丁酸类似物，用于治疗神经性疼痛。它们越来越多地被滥用，以达到欣快和分离的效果。本研究旨在确定使用加巴喷丁类药物治疗神经性疼痛的患者中药物滥用/误用和相关因素。
本研究纳入了 140 名年龄在 18 岁以上的患者。如果患者有失语症、痴呆或导致失语症或合作和认知功能障碍的疾病，则将其排除在研究之外。如果他们缺乏关于使用药物的时间长短或剂量的足够信息，也将其排除在外。使用贝克抑郁量表和贝克焦虑量表评估抑郁和焦虑状态。根据误用、滥用和相关事件术语中提供的定义，确定患者的药物滥用程度。
患者的平均年龄为 56.78 ± 14.45 岁，其中 52.1%为女性。57.9%的患者使用普瑞巴林，42.1%的患者使用加巴喷丁。普瑞巴林的剂量中位数（最小-最大）为 300（50-600）mg/天，加巴喷丁的剂量中位数为 900（300-2400）mg/天。17.9%的患者存在滥用行为。加巴喷丁类药物滥用的风险因素包括吸烟、饮酒、使用抗抑郁药、焦虑和抑郁、独居以及药物剂量和使用时间。
在开具药物并以受控方式管理治疗过程之前，询问患者的风险因素可以降低滥用率。
