Department of Biomedical, Surgical, Dental Science, University of Milan, Milan, Italy.
Eur Rev Med Pharmacol Sci. 2023 Jun;27(12):5421-5430. doi: 10.26355/eurrev_202306_32777.
Since 1967, when the osteoinduction properties of autogenous demineralized dentin matrix were discovered, autologous tooth grafts have been advocated as a viable option to autologous or heterologous bone graft. Tooth graft materials may be extracted from the patient's whole tooth using a granulating device. The aim of this study was to examine the size of granules obtained by the Tooth Transformer (TT)® device, using a laser instrument with high precision.
The TT® device can obtain bone graft material in a short period from an extracted tooth. The resulting material can act as an osteoconductive scaffold, providing a mineral substrate during resorption, including platelet growth factors and morphogenetic proteins. Different studies have investigated the dimension and behavior of various graft material particles, since the size of the grafted particles may play a role in osteogenesis and bone regeneration.
Different dimensions of granules are available: small (< 400 µm), medium (400 µm-1,000 µm) and large (1,000 µm-2,000 µm). From 4.03 µm to 100 µm the percentage of granules was 14.52 ± 1.93%. A larger part of the granules was up to 100 µm, while 85.47 ± 1.93% of the granules were from 100 µm to 1,000 µm.
85% of the granules produced were in accordance with the dimensions suggested in the literature.
自 1967 年发现自体脱矿牙本质基质的成骨特性以来，自体牙移植已被提倡作为自体或异体骨移植的可行选择。牙移植材料可以使用颗粒化装置从患者的整颗牙齿中提取。本研究旨在使用高精度的激光仪器检查 Tooth Transformer（TT）® 设备获得的颗粒大小。
TT® 设备可以在短时间内从拔出的牙齿中获得骨移植材料。由此产生的材料可以作为骨传导支架，在吸收过程中提供矿物质基质，包括血小板生长因子和形态发生蛋白。由于移植颗粒的大小可能在成骨和骨再生中发挥作用，因此不同的研究已经研究了各种移植材料颗粒的尺寸和行为。
有不同尺寸的颗粒可供选择：小（<400µm）、中（400µm-1000µm）和大（1000µm-2000µm）。从 4.03µm 到 100µm，颗粒的百分比为 14.52±1.93%。更大一部分颗粒达到 100µm，而 85.47±1.93%的颗粒在 100µm 到 1000µm 之间。
85%的颗粒符合文献中建议的尺寸。
