Department of Internal Medicine, Botucatu Medical School, UNESP - Sao Paulo State University.
Department of Neurology, Psychology and Psychiatry, Botucatu Medical School, UNESP - Sao Paulo State University.
Eur J Cancer Prev. 2024 Jan 1;33(1):73-75. doi: 10.1097/CEJ.0000000000000824. Epub 2023 Jul 3.
Glioblastoma is the most aggressive central nervous system primary tumor. Prognosis is poor, mainly due to the malignant characteristics of the tumor, such as high cell proliferation and invasiveness. CDH1 hypermethylation is linked to the invasive potential in various cancer types, but its importance is still unknown in glioblastoma. In this context, the methylation status of CDH1 was analyzed using MSP-PCR (Methylation-specific Polymerase Chain Reaction) in glioblastoma (n = 34) and normal glial tissue samples (n = 11). CDH1 hypermethylation was found in 39.4% (13/34) of the tumor samples and none of the normal glial tissue, suggesting a relation between CDH1 hypermethylation and glioblastoma ( P = 0.0195). Finally, this study showed unprecedented information that could contribute to clarifying the molecular pathways involved in the invasiveness and aggressiveness of this type of cancer.
胶质母细胞瘤是最具侵袭性的中枢神经系统原发性肿瘤。预后较差，主要归因于肿瘤的恶性特征，如高细胞增殖和侵袭性。CDH1 甲基化与多种癌症类型的侵袭潜能有关，但在胶质母细胞瘤中的重要性仍不清楚。在这种情况下，使用 MSP-PCR（甲基化特异性聚合酶链反应）分析了胶质母细胞瘤（n=34）和正常神经胶质组织样本（n=11）中的 CDH1 甲基化状态。在 39.4%（13/34）的肿瘤样本中发现 CDH1 高甲基化，而在正常神经胶质组织中则没有，这表明 CDH1 高甲基化与胶质母细胞瘤之间存在关联（P=0.0195）。最后，这项研究提供了前所未有的信息，有助于阐明这种癌症侵袭性和恶性的分子途径。
