Xu Shiji, Wang Qiang, Sun Jing, Han Ying, Hu Weiming, Wang Lei, Yan Chao-Guo
School of Chemistry & Chemical Engineering, Yangzhou University, 225002, Yangzhou, P. R. China.
Jiangsu Key Laboratory of Function Control Technology for Advanced Materials, School of Environmental and Chemical Engineering, Jiangsu Ocean University, Lianyungang 222005, Jiangsu, China.
Org Biomol Chem. 2023 Jul 19;21(28):5742-5746. doi: 10.1039/d3ob00740e.
Pd/Cu-catalyzed cascade Heck-type reactions of alkenyl halides with terminal alkynes have been developed. This research provides an efficient atom-economical approach to access a variety of highly substituted pyrrolidines in moderate to good yields. This protocol features readily available substrates, broad substrate scope, easy scale-up, high selectivities and versatile transformations.
