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一种新的使用腺病毒载体疫苗的免疫方案可有效预防猪感染非洲猪瘟病毒。

A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine.

机构信息

Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.

University of Chinese Academy of Sciences, Beijing, People's Republic of China.

出版信息

Emerg Microbes Infect. 2023 Dec;12(2):2233643. doi: 10.1080/22221751.2023.2233643.

DOI:10.1080/22221751.2023.2233643
PMID:37401832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10348041/
Abstract

African swine fever (ASF) is an acute and highly contagious lethal infectious disease in swine that severely threatens the global pig industry. At present, a safe and efficacious vaccine is urgently required to prevent and control the disease. In this study, we evaluated the safety and immunogenicity of replication-incompetent type-2 adenoviruses carrying African swine fever virus (ASFV) antigens, namely (p30), (p54), (CD2v), (p72), and (p72 chaperone). A vaccine cocktail delivered by simultaneous intramuscular (IM) and intranasal (IN) administration robustly elicited both systemic and mucosal immune responses against AFSV in mice and swine and provided highly effective protection against the circulating ASFV strain in farmed pigs. This multi-antigen cocktail vaccine was well tolerated in the vaccinated animals. No significant interference among antigens was observed. The combined IM and IN vaccination using this adenovirus-vectored antigen cocktail vaccine warrants further evaluation for providing safe and effective protection against ASFV infection and transmission.

摘要

非洲猪瘟（ASF）是一种严重威胁全球养猪业的急性、高度传染性和致命性传染病。目前，迫切需要一种安全有效的疫苗来预防和控制这种疾病。在本研究中，我们评估了携带非洲猪瘟病毒（ASFV）抗原的复制缺陷型 2 型腺病毒（p30）、（p54）、（CD2v）、（p72）和（p72 伴侣蛋白）的安全性和免疫原性。通过同时肌肉内（IM）和鼻内（IN）给药的疫苗鸡尾酒在小鼠和猪中强烈诱导针对 ASF 的全身和黏膜免疫反应，并为农场饲养的猪提供针对循环 ASF 株的高度有效保护。这种多抗原鸡尾酒疫苗在接种动物中具有良好的耐受性。在接种的动物中没有观察到抗原之间的显著干扰。使用这种腺病毒载体抗原鸡尾酒疫苗进行联合 IM 和 IN 免疫接种值得进一步评估，以提供针对 ASF 感染和传播的安全有效保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/1088277f956b/TEMI_A_2233643_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/a66efc98d073/TEMI_A_2233643_F0001_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/69fecdca778b/TEMI_A_2233643_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/7b486b5d73a2/TEMI_A_2233643_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/7962bfe60198/TEMI_A_2233643_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/1f0b97fa7653/TEMI_A_2233643_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/1088277f956b/TEMI_A_2233643_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/a66efc98d073/TEMI_A_2233643_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/97b76ba44c06/TEMI_A_2233643_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/69fecdca778b/TEMI_A_2233643_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/7b486b5d73a2/TEMI_A_2233643_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/7962bfe60198/TEMI_A_2233643_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/1f0b97fa7653/TEMI_A_2233643_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b0/10348041/1088277f956b/TEMI_A_2233643_F0007_OC.jpg

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