Arce Bernardo, Grañana Nora
Psicologo.
Médica Neuróloga.
Rev Fac Cien Med Univ Nac Cordoba. 2023 Jun 30;80(2):126-133. doi: 10.31053/1853.0605.v80.n2.40533.
Patients with breast cancer may experience cognitive difficulties from chemotherapy. This alteration is called Chemoinduced Cognitive Impairment, also known as Chemobrain or Chemofog.
To identify the cognitive profile and the characteristics of the neuropsychological assessment in this population. Method: PubMed, SpringerLink and SciELO databases were revised. Articles from 1994 to September 2021 were selected. Keywords related to the study topic were used.
Chemotherapy can cause cognitive impairment between 15 and 50% of women. This disturbance may be from multiple aetiologies and can be associated with biological factors and functional and/or structural changes of the CNS. Sociodemographic, clinical and psychological factors should be considered as modulating variables. It manifests mainly with memory problems, executive function, attention and processing speed impairment. It can be measured through neuropsychological evaluation instruments.
We suggest that chemo-induced cognitive impairment should be included to the informed consent. Further development of longitudinal studies complemented with neuroimages that allow us to advance in the knowledge of this problem is recommended. A neuropsychological protocol is proposed, which includes screening tests, clinical scales, specific cognitive tests and quality of life questionnaires, within the recommendations of the International Cognition and Cancer Task Force.
乳腺癌患者可能会因化疗而出现认知困难。这种改变被称为化疗引起的认知障碍，也被称为化疗脑或化疗迷雾。
确定该人群的认知特征以及神经心理学评估的特点。方法：对PubMed、SpringerLink和SciELO数据库进行了检索。选取了1994年至2021年9月的文章。使用了与研究主题相关的关键词。
化疗可导致15%至50%的女性出现认知障碍。这种紊乱可能由多种病因引起，并且可能与中枢神经系统的生物学因素以及功能和/或结构变化有关。社会人口统计学、临床和心理因素应被视为调节变量。它主要表现为记忆问题、执行功能、注意力和处理速度受损。可以通过神经心理学评估工具进行测量。
我们建议在知情同意书中应包含化疗引起的认知障碍。建议进一步开展纵向研究，并辅以神经影像学检查，以便我们在该问题的认识上取得进展。在国际认知与癌症特别工作组的建议范围内，提出了一种神经心理学方案，其中包括筛查测试、临床量表、特定认知测试和生活质量问卷。
