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环境辅助量子模型研究由于碱基互变异构导致的 RNA-DNA 错误相关性。

Environment assisted quantum model for studying RNA-DNA-error correlation created due to the base tautomery.

机构信息

Department of Energy Engineering, Sharif University of Technology, P.O. Box 11365-9516, Tehran, Iran.

Department of Chemistry, Bu-Ali Sina University, Hamedan, Iran.

出版信息

Sci Rep. 2023 Jul 4;13(1):10788. doi: 10.1038/s41598-023-38019-7.

Abstract

The adaptive mutation phenomenon has been drawing the attention of biologists for several decades in evolutionist community. In this study, we propose a quantum mechanical model of adaptive mutation based on the implications of the theory of open quantum systems. We survey a new framework that explain how random point mutations can be stabilized and directed to be adapted with the stresses introduced by the environments according to the microscopic rules dictated by constraints of quantum mechanics. We consider a pair of entangled qubits consist of DNA and mRNA pair, each coupled to a distinct reservoir for analyzing the spreed of entanglement using time-dependent perturbation theory. The reservoirs are physical demonstrations of the cytoplasm and nucleoplasm and surrounding environments of mRNA and DNA, respectively. Our predictions confirm the role of the environmental-assisted quantum progression of adaptive mutations. Computing the concurrence as a measure that determines to what extent the bipartite DNA-mRNA can be correlated through entanglement, is given. Preventing the entanglement loss is crucial for controlling unfavorable point mutations under environmental influences. We explore which physical parameters may affect the preservation of entanglement between DNA and mRNA pair systems, despite the destructive role of interaction with the environments.

摘要

自适应突变现象在进化生物学家群体中已经引起了几十年的关注。在这项研究中,我们基于开放量子系统理论的含义,提出了一种自适应突变的量子力学模型。我们调查了一个新的框架,该框架解释了随机点突变如何根据量子力学约束所规定的微观规则,通过环境引入的压力得到稳定和定向适应。我们考虑一对由 DNA 和 mRNA 对组成的纠缠量子位,每个量子位与一个不同的库耦合,以使用含时微扰理论分析纠缠的扩展。库分别是细胞质和核质以及 mRNA 和 DNA 周围环境的物理表现。我们的预测证实了环境辅助的自适应突变量子进展的作用。计算关联度作为确定双联体 DNA-mRNA 通过纠缠相关程度的度量,给出了。防止纠缠丢失对于控制环境影响下不利的点突变至关重要。我们探索了哪些物理参数可能会影响 DNA 和 mRNA 对系统之间的纠缠保存,尽管与环境的相互作用具有破坏性作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f1d/10319750/3e6e3d74a46d/41598_2023_38019_Fig1_HTML.jpg

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