Senolysis through thrombomodulation.
作者信息
Webster Corey M, van Deursen Jan M
机构信息
Buck Institute for Research on Aging, Novato, CA, USA.
Cavalry Biosciences, Novato and San Francisco, CA, USA.
出版信息
Cell Res. 2023 Aug;33(8):575-576. doi: 10.1038/s41422-023-00842-y.
Abstract
摘要
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Structure and transport mechanism of the human calcium pump SPCA1.人钙泵 SPCA1 的结构与传输机制。
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Senescent cells limit p53 activity via multiple mechanisms to remain viable.衰老细胞通过多种机制限制 p53 活性以保持存活。
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p21 produces a bioactive secretome that places stressed cells under immunosurveillance.p21 产生一种生物活性的分泌组，使应激细胞处于免疫监视之下。
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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.视网膜病变中的病理性血管生成涉及细胞衰老，并且可以通过 BCL-xL 抑制进行治疗性消除。
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Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia.重组人可溶性血栓调节蛋白可降低血浆中高迁移率族蛋白盒1的水平，同时改善实验性内毒素血症中的急性肝损伤及提高生存率。
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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.衰老相关分泌表型揭示了致癌RAS和p53肿瘤抑制因子的细胞非自主功能。
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Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity.发现一种新型的、口服活性的基于辛可宁的凝血酶受体拮抗剂（SCH 530348），具有强效抗血小板活性。
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p53 in health and disease.健康与疾病中的p53
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Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial.重组人可溶性血栓调节蛋白（ART-123）治疗弥散性血管内凝血的疗效与安全性：一项III期随机双盲临床试验结果
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