全面基因组分析揭示肺炎克雷伯氏菌中 I 型和 IV 型分泌系统的广泛多样性。
Comprehensive Genomic Analysis Reveals Extensive Diversity of Type I and Type IV Secretion Systems in Klebsiella pneumoniae.
机构信息
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
出版信息
Curr Microbiol. 2023 Jul 5;80(8):270. doi: 10.1007/s00284-023-03362-5.
The diversity and distribution of secretion systems in Klebsiella pneumoniae are unclear. In this study, the six common secretion systems (T1SS-T6SS) were comprehensively investigated in the genomes of 952 K. pneumoniae strains. T1SS, T2SS, type T subtype of T4SS, T5SS, and subtype T6SSi of T6SS were found. The findings indicated fewer types of secretion systems in K. pneumoniae than reported in Enterobacteriaceae, such as Escherichia coli. One conserved T2SS, one conserved T5SS, and two conserved T6SS were detected in more than 90% of the strains. In contrast, the strains displayed extensive diversity of T1SS and T4SS. Notably, T1SS and T4SS were enriched in the hypervirulent and classical multidrug resistance pathotypes of K. pneumoniae, respectively. The results expand the epidemiological knowledge of the virulence and transmissibility of pathogenic K. pneumoniae and contribute to identify the potential strains for safe applications.
肺炎克雷伯菌中分泌系统的多样性和分布尚不清楚。在本研究中，我们对 952 株肺炎克雷伯菌基因组中的六种常见分泌系统（T1SS-T6SS）进行了全面研究。发现了 T1SS、T2SS、T4SS 的 T 型亚类、T5SS 和 T6SS 的 T6SSi 亚类。研究结果表明，肺炎克雷伯菌的分泌系统类型比大肠杆菌等肠杆菌科报道的要少。超过 90%的菌株中存在一种保守的 T2SS、一种保守的 T5SS 和两种保守的 T6SS。相比之下，T1SS 和 T4SS 表现出广泛的多样性。值得注意的是，T1SS 和 T4SS 分别在高毒力和经典多药耐药表型的肺炎克雷伯菌中富集。研究结果扩展了对致病性肺炎克雷伯菌毒力和传播能力的流行病学认识，并有助于鉴定出具有安全应用潜力的潜在菌株。
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