高毒力的分子流行病学：一项系统评价与荟萃分析
Molecular epidemiology of hypervirulent : a systematic review and meta-analysis.
作者信息
Sanikhani Rahimeh, Moeinirad Mohammad, Shahcheraghi Fereshteh, Lari Arezou, Fereshteh Sepideh, Sepehr Amin, Salimi Afsaneh, Badmasti Farzad
机构信息
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Microbiol. 2021 Jun;13(3):257-265. doi: 10.18502/ijm.v13i3.6384.
Classical (CKp) and hypervirulent (hvKp) are two different circulating pathotypes. The aim of this study was to assess the prevalence, epidemiology and molecular relatedness of hvKps using a systemic review and meta-analysis. The data extracted from Medline, Embase, and Web of Science and finally 14 studies met the eligible criteria. To combine prevalence proportions of all studies, we performed the metaprop command embedded in the Meta package software. Totally, of 1814 isolates, 21.7% (394/1814) were hvKp. The molecular typing showed that all hvKp isolates were grouped into 50 different sequence types (STs) of them ST23, ST11, ST65 and ST86 were common. K1, K2 and K64 were dominant capsule serotypes that strongly related to ST23, ST65 and ST11, respectively. It seems that clonal group 23 (CG23) is associated with liver abscess and CG11 related to various clinical sources.
经典型（CKp）和高毒力型（hvKp）是两种不同的流行致病型。本研究的目的是通过系统评价和荟萃分析评估hvKp的流行率、流行病学及分子相关性。从Medline、Embase和科学网提取数据，最终有14项研究符合纳入标准。为合并所有研究的患病率，我们使用了Meta软件包中嵌入的metaprop命令。在总共1814株分离株中，21.7%（394/1814）为hvKp。分子分型显示，所有hvKp分离株被分为50种不同的序列型（STs），其中ST23、ST11、ST65和ST86较为常见。K1、K2和K64是主要的荚膜血清型，分别与ST23、ST65和ST11密切相关。似乎克隆群23（CG23）与肝脓肿有关，而CG11与各种临床来源有关。
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