Ferguson A V, Kasting N W
Am J Physiol. 1986 Aug;251(2 Pt 2):R425-8. doi: 10.1152/ajpregu.1986.251.2.R425.
Electrical stimulation in the subfornical organ (SFO) of conscious freely moving rats was found to increase plasma vasopressin concentrations from control values of 1.43 +/- 0.32 to poststimulation values of 22.32 +/- 4.9 pg/ml (P less than 0.01). Similar stimulation in immediately adjacent brain regions including the medial septum and hippocampal commissure caused no significant changes in plasma concentrations of this peptide hormone. These data indicate that activation of SFO neurons in conscious rats causes increased release of vasopressin from the posterior pituitary. Such data corroborate previous electrophysiological findings demonstrating that in anesthetized animals electrical stimulation in SFO results in increased excitability of antidromically identified vasopressin-secreting neurons in the supraoptic and paraventricular nuclei of the hypothalamus.
研究发现，对清醒自由活动大鼠的穹窿下器（SFO）进行电刺激，可使血浆血管加压素浓度从对照值1.43±0.32皮克/毫升升高至刺激后值22.32±4.9皮克/毫升（P<0.01）。在包括内侧隔和海马连合在内的紧邻脑区进行类似刺激，该肽类激素的血浆浓度未发生显著变化。这些数据表明，清醒大鼠SFO神经元的激活会导致垂体后叶血管加压素释放增加。这些数据证实了先前的电生理研究结果，即麻醉动物中对SFO进行电刺激会导致下丘脑视上核和室旁核中经逆向鉴定的血管加压素分泌神经元的兴奋性增加。
