Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Hamedan, Iran.
Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan, Iran.
Endocrinol Diabetes Metab. 2023 Sep;6(5):e438. doi: 10.1002/edm2.438. Epub 2023 Jul 4.
Spermatogenesis is significantly influenced by the thyroid gland. Thyroid disorders can be caused by a variety of factors. Traditionally, Ellettaria cardamomum has been used to treat a variety of ailments. The effects of E. cardamomum extract (ECE) on spermatogenesis in hypothyroid mice were investigated in this study.
In this study 42 male mice, weighing (25-35 g) were randomly divided in six groups: control group (taking normal saline, 0.5 mL/day, by oral gavage [P.O.]), hypothyroid group (taking 0.1% propylthiouracil in drinking water for 2 weeks), hypothyroid groups treated by levothyroxine (15 mg/kg/day, P.O.) and hypothyroid groups treated by ECE (100, 200 and 400 mg/kg/day, P.O.). After the end of experiments the mice were anaesthetised and blood samples were collected for hormonal analysis.
The sperm count and microscopic studies of testes were done also. Our results showed that the T , T , testosterone levels and spermatogenesis in hypothyroid animals decreased and thyroid-stimulating hormone, follicle-stimulating hormone and luteinizing hormone increased compared with control group. Treatment by ECE reverse these effects in comparison with hypothyroid group.
According to our findings, the ECE may stimulates thyroid gland function and increases testosterone and spermatogenesis.
精子发生受到甲状腺的显著影响。甲状腺疾病可能由多种因素引起。传统上，小豆蔻已被用于治疗多种疾病。本研究旨在探讨小豆蔻提取物（ECE）对甲状腺功能减退症小鼠精子发生的影响。
本研究中，将 42 只雄性小鼠（体重 25-35g）随机分为六组：对照组（每天口服生理盐水 0.5mL）、甲状腺功能减退组（饮用含 0.1%丙硫氧嘧啶的水 2 周）、甲状腺功能减退症左旋甲状腺素治疗组（15mg/kg/天，P.O.）和甲状腺功能减退症 ECE 治疗组（100、200 和 400mg/kg/天，P.O.）。实验结束后，麻醉小鼠并采集血液样本进行激素分析。
还进行了精子计数和睾丸显微镜检查。我们的结果表明，与对照组相比，甲状腺功能减退动物的 T 、 T 、睾酮水平和精子发生减少，促甲状腺激素、卵泡刺激素和黄体生成素增加。与甲状腺功能减退组相比，ECE 治疗可逆转这些影响。
根据我们的发现，ECE 可能刺激甲状腺功能，增加睾酮和精子发生。
