School of Materials Science and Engineering, Hefei University of Technology, Hefei, China.
Department of Neurology, Anhui No. 2 Provincial People's Hospital, Hefei, China.
J Biophotonics. 2024 Jan;17(1):e202300145. doi: 10.1002/jbio.202300145. Epub 2023 Oct 1.
Photobiomodulation (PBM) therapy is an innovative treatment for neurological and psychological conditions. Complex IV of the mitochondrial respiratory chain can be stimulated by red light, which increases ATP synthesis. In addition, the ion channels' light absorption causes the release of Ca which activates transcription factors and changes gene expression. Neuronal metabolism is improved by brain PBM therapy, which also promotes synaptogenesis and neurogenesis as well as anti-inflammatory. Its depression-treating potential is attracting attention for other conditions, including Parkinson's disease and dementia. Giving enough dosage for optimum stimulation using the transcranial PBM technique is challenging because of the rapidly increasing attenuation of light transmission in tissue. Different strategies like intranasal and intracranial light delivery systems have been proposed to overcome this restriction. The most recent preclinical and clinical data on the effectiveness of brain PBM therapy are studied in this review article.
光生物调节（PBM）疗法是一种针对神经和心理疾病的创新治疗方法。线粒体呼吸链复合物 IV 可以被红光刺激，从而增加 ATP 的合成。此外，离子通道的光吸收会导致 Ca 的释放，从而激活转录因子并改变基因表达。脑 PBM 疗法可以改善神经元代谢，促进突触形成和神经发生以及抗炎作用。它在治疗抑郁症方面的潜力引起了人们对其他疾病的关注，包括帕金森病和痴呆症。由于组织中光传输的衰减迅速增加，使用经颅 PBM 技术给予足够的剂量以实现最佳刺激具有挑战性。已经提出了不同的策略，如鼻内和颅内光输送系统，以克服这一限制。本文综述了脑 PBM 疗法有效性的最新临床前和临床数据。
