Hennessy Madison, Hamblin Michael R
Briarcliff High School, Briarcliff Manor, NY, USA.
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
J Opt. 2017 Jan;19(1):013003. doi: 10.1088/2040-8986/19/1/013003. Epub 2016 Dec 14.
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. The mechanism of action involves photon absorption in the mitochondria (cytochrome c oxidase), and ion channels in cells leading to activation of signaling pathways, up-regulation of transcription factors, and increased expression of protective genes. We have studied PBM for treating traumatic brain injury (TBI) in mice using a NIR laser spot delivered to the head. Mice had improved memory and learning, increased neuroprogenitor cells in the dentate gyrus and subventricular zone, increased BDNF and more synaptogenesis in the cortex. These highly beneficial effects on the brain suggest that the applications of tLLLT are much broader than at first conceived. Other groups have studied stroke (animal models and clinical trials), Alzheimer's disease, Parkinson's disease, depression, and cognitive enhancement in healthy subjects.
经颅光生物调节疗法（PBM），也称为低强度激光疗法（tLLLT），依靠使用红光/近红外光来刺激、保存和再生细胞与组织。其作用机制涉及线粒体（细胞色素c氧化酶）中的光子吸收以及细胞中的离子通道，从而导致信号通路激活、转录因子上调以及保护性基因表达增加。我们使用近红外激光光斑照射小鼠头部，研究了经颅光生物调节疗法治疗创伤性脑损伤（TBI）的效果。小鼠的记忆力和学习能力得到改善，齿状回和脑室下区的神经祖细胞增加，脑源性神经营养因子（BDNF）增加，大脑皮质中的突触形成也增多。这些对大脑极为有益的作用表明，经颅低强度激光疗法的应用范围比最初设想的要广泛得多。其他研究团队已经对中风（动物模型和临床试验）、阿尔茨海默病、帕金森病、抑郁症以及健康受试者的认知增强进行了研究。
