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使用三维有限元模型研究骨结合功能梯度生物材料种植体周围的下颌骨重塑

Mandibular bone remodeling around osseointegrated functionally graded biomaterial implant using three dimensional finite element model.

作者信息

Elleuch Sameh, Jrad Hanen, Wali Mondher, Dammak Fakhreddine

机构信息

Laboratory of Electrochemistry and Environment (LEE), National Engineering School of Sfax, ENIS, Sfax, University of Sfax, Sfax, Tunisia.

École supérieure des sciences et de la technologie de Hammam Sousse, University of Sousse, Hammam Sousse, Tunisia.

出版信息

Int J Numer Method Biomed Eng. 2023 Sep;39(9):e3750. doi: 10.1002/cnm.3750. Epub 2023 Jul 5.

DOI:10.1002/cnm.3750
PMID:37403568
Abstract

Dental implantation surgery has been progressed as one of the most efficient prosthetic technologies, however, it still fails very often and one of the main causes is the large difference between implant mechanical properties and those in welcoming bony tissues, making it problematical in osseointegration and bone remodeling. Biomaterial and tissue engineering research shows that there is a requirement in developing implants with Functionally Graded Materials (FGM). Indeed, the great potential of FGM lies not only in the field of bone tissue engineering but also in dentistry. To improve the acceptance of dental implants inside the living bone, FGM were proposed to step up the challenge of ensuring a better match of mechanical properties between biologically and mechanically compatible biomaterials. The aim of the present work is to investigate mandibular bone remodeling induced by FGM dental implant. Three-dimensional (3D) mandibular bone structure around an osseointegrated dental implant has been created to analyze the biomechanical behavior of the bone-implant system depending on implant material composition. In order to implement the numerical algorithm into ABAQUS software, UMAT subroutines and user-defined material were employed. Finite element analysis have been conducted to determine the stress distributions in implant and bony system, and to evaluate bone remodeling induced by the use of various FGM and pure titanium dental implants over the period of 48 months.

摘要

牙种植手术已发展成为最有效的修复技术之一,然而,它仍然经常失败,主要原因之一是种植体的机械性能与周围骨组织的机械性能差异很大,这使得骨整合和骨重塑存在问题。生物材料和组织工程研究表明,开发具有功能梯度材料(FGM)的种植体是有必要的。事实上,FGM的巨大潜力不仅在于骨组织工程领域,也在于牙科领域。为了提高牙种植体在活骨内的接受度,人们提出使用FGM来应对确保生物和机械兼容生物材料之间更好的机械性能匹配这一挑战。本研究的目的是研究FGM牙种植体诱导的下颌骨重塑。围绕骨整合牙种植体创建了三维(3D)下颌骨结构,以分析骨-种植体系统的生物力学行为,该行为取决于种植体材料组成。为了将数值算法应用于ABAQUS软件,采用了UMAT子程序和用户定义材料。进行了有限元分析,以确定种植体和骨系统中的应力分布,并评估在48个月期间使用各种FGM和纯钛牙种植体诱导的骨重塑。

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