Faculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for NanoIntegration (CENIDE), University of Duisburg-Essen, Universitätsstrasse 7, 45117 Essen, Germany.
Center of Medical Biotechnology (ZMB), University of Duisburg Essen, Universitätsstraße 2, 45141 Essen, Germany.
Org Biomol Chem. 2023 Jul 19;21(28):5762-5767. doi: 10.1039/d3ob00656e.
In this contribution, three deoxyestrone-based emissive lipofection agents are reported. Because of a centrally incorporated terephthalonitrile motif, these ligands can be classified as solution and solid-state emitters (SSSEs). With the attachment of tobramycin, these amphiphilic structures are able to form lipoplexes, mediating gene transfection of HeLa and HEK 293T cells.
在本研究中，报告了三种基于去氧表雄酮的发光脂质体试剂。由于中央结合的对苯二甲腈基序，这些配体可被分类为溶液和固态发光体（SSSEs）。通过连接妥布霉素，这些两亲性结构能够形成脂质体，介导 HeLa 和 HEK 293T 细胞的基因转染。
