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重度维生素B12缺乏所致精神病与癫痫发作:一例报告

Psychosis and Seizures Attributed to Severe Vitamin B12 Deficiency: A Case Report.

作者信息

Portillo Shellsea, Guevara Nehemias A, Francis-Morel Garry

机构信息

Internal Medicine, St. Barnabas Hospital Health System, Bronx, USA.

Internal Medicine, St. Barnabas Medical Center, Bronx, USA.

出版信息

Cureus. 2023 Jun 2;15(6):e39889. doi: 10.7759/cureus.39889. eCollection 2023 Jun.

DOI:10.7759/cureus.39889
PMID:37404443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10315186/
Abstract

Vitamin B12 deficiency is known to cause a variety of symptoms, including megaloblastic anemia, glossitis, and neuropsychiatric disorders. This case report describes a patient who presented with cognitive decline, psychosis, and seizures due to a severe vitamin B12 deficiency. Following treatment with vitamin supplementation therapy, the patient's condition significantly improved. The literature has also documented similar neuropsychiatric manifestations of vitamin B12 deficiency, highlighting the potential for symptom reversal with prompt and appropriate treatment. Therefore, early diagnosis and treatment of vitamin B12 deficiency are critical to preventing potentially irreversible neurological damage.

摘要

众所周知,维生素B12缺乏会导致多种症状,包括巨幼细胞贫血、舌炎和神经精神障碍。本病例报告描述了一名因严重维生素B12缺乏而出现认知能力下降、精神病和癫痫发作的患者。在接受维生素补充治疗后,患者的病情明显改善。文献中也记录了维生素B12缺乏的类似神经精神表现,强调了及时和适当治疗后症状逆转的可能性。因此,早期诊断和治疗维生素B12缺乏对于预防潜在的不可逆神经损伤至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149b/10315186/78fe8ba65747/cureus-0015-00000039889-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149b/10315186/78fe8ba65747/cureus-0015-00000039889-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149b/10315186/78fe8ba65747/cureus-0015-00000039889-i01.jpg

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本文引用的文献

1
Neuropsychiatric manifestations in vitamin B12 deficiency.维生素B12缺乏时的神经精神表现。
Vitam Horm. 2022;119:457-470. doi: 10.1016/bs.vh.2022.01.001. Epub 2022 Mar 3.
2
Reversible dementia, psychotic symptoms and epilepsy in a patient with vitamin B deficiency.一名维生素B缺乏患者出现的可逆性痴呆、精神症状和癫痫。
BMJ Case Rep. 2019 May 14;12(5):e229044. doi: 10.1136/bcr-2018-229044.
3
Cobalamin deficiency manifested with seizures, mood oscillations, psychotic features and reversible dementia in the absence of typical neurologic and hematologic signs and symptoms: a case report.
钴胺素缺乏在无典型神经和血液学体征及症状的情况下表现为癫痫发作、情绪波动、精神病性特征和可逆性痴呆:一例报告
Coll Antropol. 2013 Mar;37(1):317-9.
4
Clinical practice. Vitamin B12 deficiency.临床实践。维生素B12缺乏症。
N Engl J Med. 2013 Jan 10;368(2):149-60. doi: 10.1056/NEJMcp1113996.
5
Psychotic disorder, hypertension and seizures associated with vitamin B12 deficiency: a case report.精神障碍、高血压和与维生素 B12 缺乏相关的癫痫发作:病例报告。
Hum Exp Toxicol. 2012 Apr;31(4):410-3. doi: 10.1177/0960327111422404. Epub 2011 Oct 25.
6
Psychiatric presentations of vitamin B 12 deficiency.维生素B12缺乏的精神症状表现
J Indian Med Assoc. 2007 Jul;105(7):395-6.
7
Recurrent seizures: an unusual manifestation of vitamin B12 deficiency.反复发作性癫痫:维生素B12缺乏的一种不寻常表现。
Neurol India. 2004 Mar;52(1):122-3.
8
Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies.血清甲基丙二酸和总同型半胱氨酸测定对诊断钴胺素和叶酸缺乏症的敏感性。
Am J Med. 1994 Mar;96(3):239-46. doi: 10.1016/0002-9343(94)90149-x.
9
Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons.维生素B12类似物甲钴胺对培养的皮质神经元中谷氨酸细胞毒性的保护作用。
Eur J Pharmacol. 1993 Sep 7;241(1):1-6. doi: 10.1016/0014-2999(93)90925-8.
10
Psychiatric syndromes due to avitaminosis B 12 with normal blood and marrow.血液和骨髓正常的维生素B12缺乏所致的精神综合征
Q J Med. 1965 Jul;34(135):303-17.