Tajnur Rabeya, Rezwan Refaya, Aziz Abdul, Islam Mohammad Safiqul
Department of Pharmacy ASA University Bangladesh Dhaka Bangladesh.
Department of Pharmacy State University of Bangladesh Dhaka Bangladesh.
Health Sci Rep. 2023 Jul 2;6(7):e1377. doi: 10.1002/hsr2.1377. eCollection 2023 Jul.
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 novel coronavirus, is a highly communicable disease that gave rise to the ongoing pandemic. Despite prompt action across many laboratories in many countries, effective management of this disease is still out of reach. The focus of this review is to describe various vaccination approaches and nanomedicine-based delivery systems against COVID-19.
The articles included in this study were searched and added from different electronic databases, including PubMed, Scopus, Cochrane, Embase, and preprint databases.
Mass immunization with vaccines is currently at the forefront of COVID-19 infection control. Such vaccines are live attenuated vaccines, inactivated vaccines, nucleic acid-based vaccines, protein subunit vaccines, viral-vector vaccines, and virus-like particle platforms. However, many promising avenues are currently being explored in laboratory and clinical settings, including treatment options, prevention, diagnosis, and management of the disease. Soft nanoparticles like lipid nanoparticles (solid lipid nanoparticles (SLNPs), liposomes, nanostructured lipid carriers, nanoemulsions, and protein nanoparticles play an essential role in nanomedicine. Because of their unique and excellent properties, nanomedicines have potential applications in treating COVID-19 disease.
This review work provides an overview of the therapeutic aspects of COVID-19, including vaccination and the role of nanomedicines in the diagnosis, treatment, and prevention of COVID-19.
2019冠状病毒病（COVID-19）由新型冠状病毒SARS-CoV-2引起，是一种高传染性疾病，引发了当前的大流行。尽管许多国家的众多实验室迅速采取了行动，但对这种疾病的有效管理仍然难以实现。本综述的重点是描述针对COVID-19的各种疫苗接种方法和基于纳米医学的递送系统。
本研究纳入的文章是从不同的电子数据库中检索并添加的，包括PubMed、Scopus、Cochrane、Embase和预印本数据库。
目前，疫苗大规模免疫接种处于COVID-19感染控制的前沿。此类疫苗包括减毒活疫苗、灭活疫苗、基于核酸的疫苗、蛋白亚单位疫苗、病毒载体疫苗和病毒样颗粒平台。然而，目前在实验室和临床环境中正在探索许多有前景的途径，包括该疾病的治疗选择、预防、诊断和管理。脂质纳米颗粒（固体脂质纳米颗粒、脂质体、纳米结构脂质载体、纳米乳剂）和蛋白质纳米颗粒等软纳米颗粒在纳米医学中发挥着重要作用。由于其独特而优异的特性，纳米药物在治疗COVID-19疾病方面具有潜在应用。
本综述工作概述了COVID-19的治疗方面，包括疫苗接种以及纳米药物在COVID-19诊断、治疗和预防中的作用。
