Muhammad Mubarak, Muchimapura Supaporn, Wattanathorn Jintanaporn
Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, 123 Moo 16 Mittraphap Rd., Nai-Muang, Muang District, Khon Kaen 40002, Thailand.
Department of Physiology, Faculty of Medicine, Khon Kaen University, 123 Moo 16 Mittraphap Rd., Nai-Muang, Muang District, Khon Kaen 40002, Thailand.
Biosci Microbiota Food Health. 2023;42(3):143-151. doi: 10.12938/bmfh.2022-067. Epub 2023 Apr 24.
The human microbiota-gut-brain axis has an enormous role in the maintenance of homeostasis and health. Over the last two decades, it has received concerted research attention and focus due to a rapidly emerging volume of evidence that has established that impairment within the microbiota-gut-brain axis contributes to the development and progression of various diseases. Stroke is one of the entities identified to be associated with microbiota-gut-brain axis impairment. Currently, there are still limitations in the clinical treatment of stroke, and the presence of a non-nervous factor from gut microbiota that can alter the course of stroke presents a novel strategy towards the search for a therapeutic silver bullet against stroke. Hence, the aim herein, was to focus on the involvement of microbiota-gut-brain axis impairment in the pathogenesis stroke as well as elucidate its implications as a potent therapeutic target against stroke. The findings of studies to date have revealed and extended the role microbiota-gut-brain axis impairment in the pathogenesis of stroke, and studies have identified from both clinical and pre-clinical perspectives targets within the microbiota-gut-brain axis and successfully modulated the outcome of stroke. It was concluded that the microbiota-gut-brain axis stands as potent target to salvage the neurons in the ischemic penumbra for the treatment of stroke. Assessment of the microbiota profile and its metabolites status holds enormous clinical potentials as a non-invasive indicator for the early diagnosis and prognosis of stroke.
人类微生物群-肠-脑轴在维持体内平衡和健康方面发挥着巨大作用。在过去二十年中，由于迅速涌现的大量证据表明微生物群-肠-脑轴功能受损会导致各种疾病的发生和发展，该领域受到了一致的研究关注。中风是被确定与微生物群-肠-脑轴功能受损相关的病症之一。目前，中风的临床治疗仍存在局限性，而肠道微生物群中存在的一种可改变中风病程的非神经因素为寻找治疗中风的有效方法提供了新策略。因此，本文旨在关注微生物群-肠-脑轴功能受损在中风发病机制中的作用，并阐明其作为中风有效治疗靶点的意义。迄今为止的研究结果揭示并扩展了微生物群-肠-脑轴功能受损在中风发病机制中的作用，并且从临床和临床前角度的研究都已确定了微生物群-肠-脑轴内的靶点，并成功调节了中风的结局。得出的结论是，微生物群-肠-脑轴是挽救缺血半暗带神经元以治疗中风的有效靶点。评估微生物群谱及其代谢物状态作为中风早期诊断和预后的非侵入性指标具有巨大的临床潜力。
