Sinagra Emanuele, Pellegatta Gaia, Guarnotta Valentina, Maida Marcello, Rossi Francesca, Conoscenti Giuseppe, Pallio Socrate, Alloro Rita, Raimondo Dario, Pace Fabio, Anderloni Andrea
Endoscopy Unit, Fondazione Istituto San Raffaele-G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy.
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90100 Palermo, Italy.
Life (Basel). 2021 Jul 19;11(7):715. doi: 10.3390/life11070715.
The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer's disease, and Parkinson's disease. The complex interplay between gut microbiota and the brain, and vice versa, has recently become not only the focus of neuroscience, but also the starting point for research regarding many diseases such as inflammatory bowel diseases (IBD). The bi-directional interaction between gut microbiota and the brain is not completely understood. The aim of this review is to sum up the evidencesconcerningthe role of the gut-brain microbiota axis in ischemic stroke and to highlight the more recent evidences about the potential role of the gut-brain microbiota axis in the interaction between inflammatory bowel disease and ischemic stroke.
肠道微生物群正在成为神经发育、衰老以及包括中风、阿尔茨海默病和帕金森病在内的脑部疾病中的一个重要因素。肠道微生物群与大脑之间复杂的相互作用，反之亦然，最近不仅成为神经科学的焦点，也是许多疾病（如炎症性肠病）研究的起点。肠道微生物群与大脑之间的双向相互作用尚未完全了解。本综述的目的是总结有关肠道-脑微生物群轴在缺血性中风中作用的证据，并强调关于肠道-脑微生物群轴在炎症性肠病与缺血性中风相互作用中潜在作用的最新证据。
